Evidence map›Paper›PMID 42054246›Full record

ArticleOrganic letters2026

Deoxycyanation of Alkyl Alcohols Using Photoredox Catalysis.

Carla Hümpel, William L Lyon, Ryan E McNamee, David W C MacMillan, Jingjia Chen

Abstract read
In one paragraph

Article in Organic letters, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Carla HümpelMerck Center for Catalysis at Princeton University, Princeton, New Jersey 08544, United States.
William L LyonMerck Center for Catalysis at Princeton University, Princeton, New Jersey 08544, United States.ORCID 0000-0002-7451-4755
Ryan E McNameeMerck Center for Catalysis at Princeton University, Princeton, New Jersey 08544, United States.
David W C MacMillanMerck Center for Catalysis at Princeton University, Princeton, New Jersey 08544, United States.ORCID 0000-0001-6447-0587
Jingjia ChenMerck Center for Catalysis at Princeton University, Princeton, New Jersey 08544, United States.ORCID 0000-0002-1824-6688

Funding

Photoredox Catalysis Applications in Organometallics and Chemical BiologyR35GM134897 · NIGMS · PRINCETON UNIVERSITY · PI David W MacMillan · 2020 to 2026
$6.3M
NIGMS NIH HHS R35 GM134897
6 · The paper itself

Abstract

Cyano groups represent an important class of functional motifs in medicinal chemistry given their synthetic versatility and capacity to engage in essential interactions with biological targets. However, the synthesis of sterically hindered alkyl nitriles remains challenging, and, furthermore, traditional methods often rely on toxic cyanide sources. Herein, we report a photoredox-catalyzed, metal-free deoxycyanation of alkyl alcohols that allows rapid access to a wide array of 1°, 2°, and 3° cyanides using the easily handled, low-toxicity, tosyl cyanide reagent.

Identifiers

PMID42054246
PMCPMC13185116

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.