ArticleEinstein (Sao Paulo, Brazil)2026
Accuracy of oxidative stress markers for predicting delayed graft function lasting longer than a week in deceased-donor kidney transplantation.
Article in Einstein (Sao Paulo, Brazil), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo assess the accuracy of oxidative stress markers in predicting delayed graft function (DGF) lasting more than one week after deceased-donor kidney transplantation (KTx).
methodsA translational pilot study was carried out and a five-step hierarchical diagnostic accuracy strategy was applied to evaluate the predictive value of oxidative stress markers for DGF >7 days in adult patients with end-stage kidney disease undergoing deceased-donor KTx. Statistics comprise multiple conventional methods, C-statistics, and diagnostic test performance measures.
resultsCohort analysis of 27 consecutive patients revealed that 33.3% (9/27) developed DGF >7 days. Assessment of the oxidative stress markers selected in the first statistical step comparing donors and controls revealed a significant correlation of the DGF duration with the recipient's protein oxidation (ρ=0.466; p=0.022) as well as donor's hydrogen peroxide (ρ=-0.489; p<0.014). The areas under the curve were 0.683 (95% confidence interval [95%CI], 0.458-0.859; p=0.224) and 0.746 (95%CI=0.534-0.897; p=0.019), respectively. A cutoff of ≤14 μM H2O2 had the highest level of discriminating power for predicting DGF >7 days. The sensitivity, specificity, positive predictive value, negative predictive value, and overall diagnostic accuracy to identify patients at risk for experiencing DGF >7 days was 85.7%, 61.1%, 46.1%, 91.7%, and 68%, respectively.
conclusionDonor hydrogen peroxide was identified as a potential predictor of DGF >7 days in patients who underwent deceased-donor KTx. A cut-off value of ≤14 μmol/L is suggested to stratify patients at high risk of requiring dialysis beyond the first post-transplant week.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.