Evidence map›Paper›PMID 42053981›Full record

Observational studyEchocardiography (Mount Kisco, N.Y.)2026

Sex Differences Among Patients With Aortic Stenosis Undergoing Transcatheter Aortic Valve Replacement: A Single-Center Observational Study.

Tomoo Nagai, Azusa Tanaka, Yohei Ohno, Kaho Hashimoto, Satoshi Noda, Hitomi Horinouchi, Junichi Miyamoto, Tsutomu Murakami, Norihiko Kamioka, Koichiro Yoshioka and 1 more

Abstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Echocardiography (Mount Kisco, N.Y.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Tomoo NagaiDepartment of Cardiology, Kawasaki Municipal Ida Hospital, Kawasaki, Japan.ORCID https://orcid.org/0000-0002-1552-6369
Azusa TanakaDepartment of Medical Technology, Tokai University School of Medicine Hospital, Isehara, Japan.
Yohei OhnoDivision of Cardiology, Department of Internal Medicine, Tokai University School of Medicine, Isehara, Japan.
Kaho HashimotoDivision of Cardiology, Department of Internal Medicine, Tokai University School of Medicine, Isehara, Japan.
Satoshi NodaDivision of Cardiology, Department of Internal Medicine, Tokai University School of Medicine, Isehara, Japan.
Hitomi HorinouchiDivision of Cardiology, Department of Internal Medicine, Tokai University School of Medicine, Isehara, Japan.
Junichi MiyamotoDivision of Cardiology, Department of Internal Medicine, Tokai University School of Medicine, Isehara, Japan.
Tsutomu MurakamiDivision of Cardiology, Department of Internal Medicine, Tokai University School of Medicine, Isehara, Japan.
Norihiko KamiokaDivision of Cardiology, Department of Internal Medicine, Tokai University School of Medicine, Isehara, Japan.
Koichiro YoshiokaDivision of Cardiology, Department of Internal Medicine, Tokai University School of Medicine, Isehara, Japan.
Yuji IkariDivision of Cardiology, Department of Internal Medicine, Tokai University School of Medicine, Isehara, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionThis study aimed to elucidate gender differences in cardiac function among patients undergoing aortic valve replacement (TAVR) for severe aortic stenosis (AS) and to clarify their clinical implications for outcomes.

methodsWe retrospectively evaluated 550 consecutive patients with severe AS treated between January 2017 and August 2022. Patients with hemodialysis, valve-in-valve procedures, and unsuccessful procedures were excluded.

resultsThe final study cohort included 514 patients who underwent successful TAVR (84 ± 5 years, 339 females). Female patients had a smaller physique and fewer atherosclerotic diseases, and chronic obstructive pulmonary diseases. Sizes of left ventricle and aortic valve were smaller in women even after the corrections by physique. Additionally, in women, left ventricular diastolic function indices such as eft atrial volume index (LAVI) and E/e' were deteriorated, while left ventricular remodeling expressed by relative wall thickness (RWT) and the clinical AS stage were more advanced. There were no sex differences in 1-year outcomes of TAVR. However, multiple regression analyses revealed that predictors for cardiovascular events in women were clinical frailty scale, LAVI and RWT (odds ratio [OR]: 1.57, p = 0.017; OR: 1.01, p = 0.020; OR: 45.21, p < 0.001; respectively), whereas predictors in men were atrial fibrillation and past smoking (OR: 4.01, p = 0.008; OR: 2.88, p = 0.049; respectively).

conclusionsWomen TAVR recipients had worse left ventricular diastolic function and left ventricular remodeling, which had significant impacts on the TAVAR outcomes. Early interventions may be beneficial especially for women.

Indexed as

Aortic Valve StenosisEchocardiographyTranscatheter Aortic Valve ReplacementVentricular Function, LeftAged, 80 and overAortic ValveFemaleHeart VentriclesHumansMaleRetrospective StudiesSeverity of Illness IndexSex FactorsTreatment Outcomeaortic stenosisgenderoutcometranscatheter aortic valve replacement

Identifiers

PMID42053981
PMCPMC13358680

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.