Evidence map›Paper›PMID 42053914›Full record

ArticleMikrochimica acta2026

A hierarchical dual-lock mechanism empowered epifluidic patch for rapid glucose feedback in exercise-induced sweating.

Zhu Yang, Mohamed Ishag Hassan Gama, Saminu Abdullahi, Mubashir Ali, David Chieng, Chiew Foong Kwong, Pushpendu Kar, Zedong Nie

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In one paragraph

Article in Mikrochimica acta, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Zhu YangShenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, 518055, China.
Mohamed Ishag Hassan GamaShenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, 518055, China.
Saminu AbdullahiShenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, 518055, China.
Mubashir AliShenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, 518055, China.
David ChiengUniversity of Nottingham Ningbo China, Ningbo, 315100, China.
Chiew Foong KwongUniversity of Nottingham Ningbo China, Ningbo, 315100, China.
Pushpendu KarUniversity of Nottingham Ningbo China, Ningbo, 315100, China.
Zedong NieShenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, 518055, China. zd.nie@siat.ac.cn.

Funding

National Natural Science Foundation of China 62173318 (ZN)Noncommunicable Chronic Diseases- National Science 2024ZD0532000Science and Technology Service Net- work Plan of CAS- Huangpu Special Project STS-HP- 202203 (ZN)Technology Major Project 2024ZD0532002
6 · The paper itself

Abstract

A wearable epifluidic patch featuring a hierarchical dual-lock mechanism is introduced. Tetrahedral DNA nanostructures co-localize enzymes at defined spacing to promote substrate channeling and accelerate kinetics, while a gelatin hydrogel stabilizes the enzymatic microenvironment during hydration cycles, ensuring uniform reaction conditions for homogeneous signal formation. This design produced a visible glucose-responsive signal within 30 s, with a linear range of 50–400 µM and a detection limit of 9.98 µM. Integrated with passive microfluidics and smartphone imaging, the patch enables sequential sampling in human trials conducted during physical exercise. The hierarchical immobilization method, device design, and system integration outlined demonstrate a platform for intuitive, electronics-free colorimetric sensing in dynamic environments.

Indexed as

Biosensing TechniquesExerciseGlucoseSweatColorimetryDNA NanostructuresGelatinGlucose OxidaseHumansHydrogelsLimit of DetectionMicrofluidic Analytical TechniquesWearable Electronic DevicesGelatinGlucoseGlucose OxidaseHydrogelsColorimetric sensorsDNA nanostructuresEpifluidic patchExercise-induced sweat glucoseHierarchical dual-lock mechanism

Identifiers

PMID42053914

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.