Evidence map›Paper›PMID 42053913›Full record

ReviewReviews in endocrine & metabolic disorders2026

Hypothalamic regulation of energy homeostasis: Quo vadis.

Miguel López, Jeffrey M Friedman

Abstract readReview
In one paragraph

Review in Reviews in endocrine & metabolic disorders, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Miguel LópezNeurObesity Group, Department of Physiology, CIMUS, University of Santiago de Compostela, Santiago de Compostela, 15782, Spain. m.lopez@usc.es.ORCID 0000-0002-7823-1648
Jeffrey M FriedmanLaboratory of Molecular Genetics, Howard Hughes Medical Institute, The Rockefeller University, New York, NY, USA. friedj@rockefeller.edu.ORCID 0000-0003-2152-0868

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The hypothalamus orchestrates energy homeostasis via specialized neuronal populations and glial cells that integrate interoceptive signals, such as leptin, glucose, and fatty acids, through key intracellular energy sensors, like AMP-activated protein kinase (AMPK). This enables the hypothalamus to coordinate behavioral, autonomic, and neuroendocrine responses that regulate adipose mass and metabolism. This foundational Neuroendocrinology paradigm, forged through centuries of research, drives the mission of this Special Issue. From the cellular complexity of hypothalamic circuits and their hormonal regulation, to sex dimorphism and clinical relevance, as well as cutting-edge advances, such as single-cell hypothalamic mapping, circuit dynamics, and emerging therapeutic frontiers, this collection offers a comprehensive roadmap to the past, present and especially the future of hypothalamic regulation of energy homeostasis.

Indexed as

Energy MetabolismHomeostasisHypothalamusAnimalsHumansEnergy homeostasisHypothalamusMetabolismNeuroendocrinologyObesity

Identifiers

PMID42053913
PMCPMC13246902

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.