Evidence map›Paper›PMID 42053894›Full record

ArticleCEN case reports2026

Carbon dioxide contrast angiography-and computed tomography-guided percutaneous embolization of the renal allograft artery in a patient with graft intolerance syndrome and iodinated contrast allergy: a case report.

Takahiro Shinzato, Akira Imaizumi, Shigeo Hara, Kojiro Nagai, Jiaowei Guo, Cong Xia, Takao Okawa, Kenta Ito, Masaaki Murakami, Ken Matsuo and 2 more

Abstract readCase Reports
In one paragraph

Article in CEN case reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

12 authors.

Takahiro ShinzatoDepartment of Nephrology, Shizuoka General Hospital, Shizuoka, Japan. shinzatotakahiro@gmail.com.ORCID 0000-0001-5705-7612
Akira ImaizumiDepartment of Radiology, Shizuoka General Hospital, Shizuoka, Japan.
Shigeo HaraDepartment of Diagnostic Pathology, Kobe City Medical Center General Hospital, Kobe, Japan.
Kojiro NagaiDepartment of Nephrology, Shizuoka General Hospital, Shizuoka, Japan.
Jiaowei GuoDepartment of Nephrology, The Second Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, China.
Cong XiaDepartment of Nephrology, The Second Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, China.
Takao OkawaDepartment of Nephrology, Shizuoka General Hospital, Shizuoka, Japan.
Kenta ItoDepartment of Nephrology, Shizuoka General Hospital, Shizuoka, Japan.
Masaaki MurakamiDepartment of Nephrology, Shizuoka General Hospital, Shizuoka, Japan.
Ken MatsuoDepartment of Nephrology, Shizuoka General Hospital, Shizuoka, Japan.
Satoshi TanakaDepartment of Nephrology, Shizuoka General Hospital, Shizuoka, Japan.
Kiyoshi MoriDepartment of Nephrology, Shizuoka General Hospital, Shizuoka, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Graft intolerance syndrome (GIS) is a well-recognized complication after kidney allograft failure, characterized by fever, graft pain, and systemic inflammation. Management options include continued immunosuppression, graft nephrectomy, and renal artery embolization, each associated with specific risks. We report a case of GIS successfully treated with percutaneous renal allograft artery embolization using carbon dioxide angiography in a patient with iodinated contrast allergy. A 66-year-old woman with autosomal dominant polycystic kidney disease underwent living-donor kidney transplantation and later developed chronic allograft dysfunction, eventually resuming hemodialysis. Following immunosuppression tapering, she presented with recurrent fever and pain over the renal allograft. Despite broad-spectrum antibiotic therapy, her symptoms persisted and imaging showed no abscess formation. Repeated blood cultures were negative. Allograft biopsy revealed extensive tissue necrosis with interstitial inflammation and vascular thrombosis. Multiple donor-specific anti-human leukocyte antigen antibodies with high mean fluorescence intensity were detected, suggesting ongoing alloimmune sensitization. Based on the clinical course and investigations, GIS was diagnosed. Given the high surgical risk and contrast allergy, percutaneous embolization of the renal allograft artery was performed using a combination of carbon dioxide angiography and CT guidance. Clinical symptoms improved promptly after the procedure, allowing discontinuation of calcineurin inhibitor therapy and steroid tapering, with no recurrence during follow-up. This case highlights carbon dioxide contrast angiography- and computed tomography-guided renal artery embolization as a safe and effective minimally invasive treatment option for GIS, particularly in patients unsuitable for iodinated contrast media or surgical nephrectomy.

Indexed as

Contrast MediaDrug HypersensitivityEmbolization, TherapeuticKidney TransplantationRenal ArteryAgedAllograftsAngiographyCarbon DioxideFemaleHumansLiving DonorsPolycystic Kidney, Autosomal DominantTomography, X-Ray ComputedTreatment OutcomeCarbon DioxideContrast MediaGraft intolerance syndromeIodinated contrast allergyRenal allograft artery embolization

Identifiers

PMID42053894
PMCPMC13128999

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