Evidence map›Paper›PMID 42053890›Full record

ArticleAntonie van Leeuwenhoek2026

Catalase is a critical virulence factor in Aeromonas schubertii infection of snakehead fish (Channa argus).

Mengzhen Jiang, Haiyan Gong, Qing Wang, Han Lin, Yueming Hu, Hua Li, Jingyang Sun, Kesong Chen, Biao Jiang, Wei Li and 2 more

Abstract read
PubMed Publisher
In one paragraph

Article in Antonie van Leeuwenhoek, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Mengzhen JiangGuangzhou Key Laboratory of Aquatic Animal Diseases and Waterfowl Breeding, Innovative Institute of Animal Healthy Breeding, College of Animal Sciences and Technology, Zhongkai University of Agriculture and Engineering, Guangzhou, 510225, China.
Haiyan GongChinese Academy of Fishery Sciences/Key Laboratory of Fishery Drug Development, Ministry of Agriculture and Rural Affairs/Key Laboratory of Aquatic Animal Immune Technology of Guangdong Province, Pearl River Fisheries Research Institute, Guangzhou, 510380, China.
Qing WangChinese Academy of Fishery Sciences/Key Laboratory of Fishery Drug Development, Ministry of Agriculture and Rural Affairs/Key Laboratory of Aquatic Animal Immune Technology of Guangdong Province, Pearl River Fisheries Research Institute, Guangzhou, 510380, China.
Han LinGuangzhou Key Laboratory of Aquatic Animal Diseases and Waterfowl Breeding, Innovative Institute of Animal Healthy Breeding, College of Animal Sciences and Technology, Zhongkai University of Agriculture and Engineering, Guangzhou, 510225, China.
Yueming HuGuangzhou Key Laboratory of Aquatic Animal Diseases and Waterfowl Breeding, Innovative Institute of Animal Healthy Breeding, College of Animal Sciences and Technology, Zhongkai University of Agriculture and Engineering, Guangzhou, 510225, China.
Hua LiGuangzhou Key Laboratory of Aquatic Animal Diseases and Waterfowl Breeding, Innovative Institute of Animal Healthy Breeding, College of Animal Sciences and Technology, Zhongkai University of Agriculture and Engineering, Guangzhou, 510225, China.
Jingyang SunGuangzhou Key Laboratory of Aquatic Animal Diseases and Waterfowl Breeding, Innovative Institute of Animal Healthy Breeding, College of Animal Sciences and Technology, Zhongkai University of Agriculture and Engineering, Guangzhou, 510225, China.
Kesong ChenGuangzhou Key Laboratory of Aquatic Animal Diseases and Waterfowl Breeding, Innovative Institute of Animal Healthy Breeding, College of Animal Sciences and Technology, Zhongkai University of Agriculture and Engineering, Guangzhou, 510225, China.
Biao JiangGuangzhou Key Laboratory of Aquatic Animal Diseases and Waterfowl Breeding, Innovative Institute of Animal Healthy Breeding, College of Animal Sciences and Technology, Zhongkai University of Agriculture and Engineering, Guangzhou, 510225, China.
Wei LiGuangzhou Key Laboratory of Aquatic Animal Diseases and Waterfowl Breeding, Innovative Institute of Animal Healthy Breeding, College of Animal Sciences and Technology, Zhongkai University of Agriculture and Engineering, Guangzhou, 510225, China.
Youlu SuGuangzhou Key Laboratory of Aquatic Animal Diseases and Waterfowl Breeding, Innovative Institute of Animal Healthy Breeding, College of Animal Sciences and Technology, Zhongkai University of Agriculture and Engineering, Guangzhou, 510225, China.
Chun LiuGuangzhou Key Laboratory of Aquatic Animal Diseases and Waterfowl Breeding, Innovative Institute of Animal Healthy Breeding, College of Animal Sciences and Technology, Zhongkai University of Agriculture and Engineering, Guangzhou, 510225, China. liuchun@zhku.edu.cn.

Funding

Science and Technology Commissioner Poverty Alleviation Special Project of Guangdong KTP20210125Science and Technology Commissioner Poverty Alleviation Special Project of Guangzhou 2023E04J1235Science and Technology Commissioner Poverty Alleviation Special Project of Jiangmen 2024760000380010118
6 · The paper itself

Abstract

Aeromonas schubertii is an emerging fish pathogen that causes visceral nodules and high mortality in snakehead (Channa argus), but the molecular basis of its virulence remains poorly understood. Catalase detoxifies host-derived hydrogen peroxide and may be critical for pathogenesis. In this study, we constructed an isogenic catalase-deficient mutant (Δcat) of A. schubertii and its complemented strain (C-cat) to evaluate the contribution of catalase to pathogenesis. The results showed that deletion of catalase did not affect growth or colony morphology but significantly reduced catalase activity, decreased hydrogen-peroxide tolerance more than 100-fold, and impaired survival at mildly acidic pH 6. In RAW264.7 macrophages, Δcat showed more than twofold lower intracellular survival after 6h, but this effect was partially mitigated in C-cat. During immersion challenge of juvenile snakehead, cumulative mortalities at 14 days were 100% for wild-type A. schubertii, 0% for Δcat, and 50% for C-cat. These findings demonstrated that catalase-mediated catalase activity was indispensable for oxidative stress resistance, intracellular persistence, and full virulence of A. schubertii, and highlighted catalase as a potential prophylactic target in aquaculture disease control.

Indexed as

AeromonasCatalaseFish DiseasesGram-Negative Bacterial InfectionsVirulence FactorsAnimalsFishesHydrogen PeroxideMacrophagesMiceOxidative StressRAW 264.7 CellsVirulenceCatalaseHydrogen PeroxideVirulence FactorsAeromonas schubertiiCatalaseOxidative stressSnakehead fishVirulence

Identifiers

PMID42053890

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.