Evidence map›Paper›PMID 42053878›Full record

ArticleJapanese journal of ophthalmology2026

Secondary corneal amyloidosis in a patient with Meesmann corneal dystrophy.

Jini Qiu, Yue Li, Rongrong Cai, Chaoran Zhang

Abstract readCase Reports
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In one paragraph

Article in Japanese journal of ophthalmology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Jini Qiu *Eye Institute and Department of Ophthalmology, Eye & ENT Hospital, Fudan University, Shanghai, China.
Yue Li *Eye Institute and Department of Ophthalmology, Eye & ENT Hospital, Fudan University, Shanghai, China.
Rongrong CaiDepartment of Pathology, Eye & ENT Hospital, Fudan University, Shanghai, China.
Chaoran ZhangEye Institute and Department of Ophthalmology, Eye & ENT Hospital, Fudan University, Shanghai, China. zhangchaoran@hotmail.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundMeesmann corneal dystrophy (MCD) is a rare autosomal dominant corneal disorder characterized by recurrent epithelial erosions. While secondary corneal amyloidosis (SCA) is well-documented in chronic inflammatory disorders, its occurrence in MCD has not been previously described. CASE: Here we first report a case of concurrent MCA and SCA, the diagnosis was confirmed through clinical evaluation, Anterior segment optical coherence tomography, in vivo laser confocal microscopy, and histopathological examination. Genetic testing identified a novel KRT12 mutation (c.1292G>C, p.R431P) in both the patient and her affected father, though the father exhibited no signs of SCA.

conclusionsSCA may develop as a rare complication in patients with long-standing MCD, potentially complicating the diagnosis.

Indexed as

AmyloidosisCorneaCorneal DiseasesCorneal Dystrophy, Juvenile Epithelial of MeesmannDNAKeratin-12MutationDNA Mutational AnalysisFemaleHumansMicroscopy, ConfocalMiddle AgedTomography, Optical CoherenceVisual AcuityDNAKeratin-12KRT12 protein, humanIn vivo laser confocal microscopyKeratin12Meesmann corneal dystrophySecondary corneal amyloidosis

Identifiers

PMID42053878

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.