ArticleMolecular and cellular biochemistry2026
Elevated placental inflammation as a mediator of adverse outcomes in gestational diabetes mellitus.
Article in Molecular and cellular biochemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Gestational diabetes mellitus (GDM) is a prevalent pregnancy complication associated with adverse maternal and neonatal outcomes. This study aims to investigate the expression of key inflammatory markers - tumor necrosis factor-α (TNF-α), interleukin-10 (IL-10), interleukin-6 (IL-6), and nuclear-factor kappa-light chain of B (NFκB) in the placental tissue of GDM and non-GDM women. Additionally, the study explores associations between these markers and neonatal characteristics, placental dimensions, and resolvins levels. This cross-sectional study included 416 singleton pregnant women, comprising 209 with GDM and 207 non-GDM. Placental protein and mRNA expression levels of TNF-α, IL-10, IL-6, and NFκB were measured using ELISA and RT-qPCR. Associations between resolvins and inflammatory markers were also assessed. Placental protein levels of TNF-α, IL-10, and NFκB, as well as gene expression levels of IL-6, were elevated in the GDM group. Furthermore, TNF-α was negatively associated with major axis, thickness and center and cord insertion. Inflammatory markers were negatively associated with head circumference at birth. A negative association was found between placental resolvin E1 (RvE1) levels and the inflammatory markers IL-10, NFκB, and TNF-α. The study highlights the association between pro-inflammatory and pro-resolving mediators in the placenta, providing insights into GDM and its adverse outcomes.
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