Trial reportSupportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer2026
Exercise as supportive care in advanced cancer-related weight loss: a feasibility study comparing patients with and without severe weight loss.
Trial report in Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06651125 (EXPLORING the IMPACT of SUPERVISED PHYSICAL ACTIVITY INTERVENTION on CACHECTIC CANCER PATIENTS), which is not on this map. Not yet cited in PubMed.
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The trial behind it
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EXPLORING the IMPACT of SUPERVISED PHYSICAL ACTIVITY INTERVENTION on CACHECTIC CANCER PATIENTS: a PRELIMINARY STUDY
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeCancer cachexia affects up to 80% of patients with advanced cancer. While exercise has shown benefits for early-stage cancer patients, its role in managing cachexia remains unclear. This study examined whether severe weight loss impedes the benefits of exercise in cancer patients.
methodsThis prospective study analyzed the feasibility and efficacy of a 12-week supervised exercise program in cancer patients with BMI-adjusted weight loss grades 3-4. Feasibility was the primary outcome and was evaluated through attrition, attendance, and safety, while secondary outcomes included changes in nutritional status, physical performance, exercise levels, and fatigue. Outcomes were compared with those of matched cancer patients without advanced BMI-adjusted weight loss who followed the same exercise program.
resultsTwenty-three patients with BMI-adjusted weight loss grades 3-4 were enrolled and 14 completed the program, attending an average of 17.1 ± 4.3/24 sessions. No adverse events occurred. Intervention improved endurance (+7.06% of theoretical 6MWT distance, p < 0.001). Positive trends emerged for lower limb strength (+2.69 repetitions at 30-s sit-to-stand test, p = 0.005), lean mass (+1.78 kg, p = 0.003), and dietary intake (+ 2.5/10 SEFI, p = 0.003). Functional benefits were also observed in patients without weight loss (n = 14, endurance = +11.33%, lower limb strength = +4, p < 0.001).
conclusionThe exercise intervention demonstrated promising efficacy in managing cancer weight loss, providing benefits like those observed in non-cachectic patients, with added gains in nutritional status. While no exercise-related adverse events occurred, feasibility criteria were only partially met due to a higher-than-expected attrition rate. Further research is needed to optimize recruitment strategies, energetic balance, and tailor interventions for this population.
trial registrationThe study is registered on ClinicalTrial.gov (Trial registration: NCT06651125).
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