Evidence map›Paper›PMID 42053710›Full record

ArticleBulletin of experimental biology and medicine2026

Generation of an Induced Pluripotent Stem Cell Line from a Duchenne Muscular Dystrophy Patient Carrying the DMD p.Ser429Ter (c.1286C>G) Nonsense Mutation.

I O Panchuk, O V Grigorieva, E V Kurshakova, S E Nagieva, O A Shchagina, O A Levchenko, V O Pozhitnova, E S Voronina, V Yu Tabakov, S A Smirnikhina and 1 more

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Article in Bulletin of experimental biology and medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

I O PanchukResearch Centre for Medical Genetics, Moscow, Russia. panchuk_io@mail.ru.
O V GrigorievaResearch Centre for Medical Genetics, Moscow, Russia.
E V KurshakovaResearch Centre for Medical Genetics, Moscow, Russia.
S E NagievaResearch Centre for Medical Genetics, Moscow, Russia.
O A ShchaginaResearch Centre for Medical Genetics, Moscow, Russia.
O A LevchenkoResearch Centre for Medical Genetics, Moscow, Russia.
V O PozhitnovaResearch Centre for Medical Genetics, Moscow, Russia.
E S VoroninaResearch Centre for Medical Genetics, Moscow, Russia.
V Yu TabakovResearch Centre for Medical Genetics, Moscow, Russia.
S A SmirnikhinaResearch Centre for Medical Genetics, Moscow, Russia.
A V LavrovResearch Centre for Medical Genetics, Moscow, Russia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

An induced pluripotent stem cell (iPSC) line was successfully generated from dermal fibroblasts of a patient with Duchenne muscular dystrophy (DMD) harboring the pathogenic nonsense variant c.1286C>G (p.Ser429Ter) in the DMD gene using non-integrating Sendai virus reprogramming. The iPSC clone exhibited typical pluripotent stem cell morphology, expressed key pluripotency markers (OCT4, SSEA4, NANOG, and TRA-1-60), and retained trilineage differentiation potential. The cell line had a normal karyotype, and elimination of reprogramming vectors (OCT3/4, SOX2, KLF4, and c-MYC) was confirmed. This isogenic cell model provides a valuable platform for investigating DMD pathogenesis associated with this specific mutation and for developing targeted therapeutic approaches, including CRISPR/Cas9-mediated gene correction.

Indexed as

Codon, NonsenseDystrophinInduced Pluripotent Stem CellsMuscular Dystrophy, DuchenneCell DifferentiationCell LineCellular ReprogrammingFibroblastsHumansKruppel-Like Factor 4MaleOctamer Transcription Factor-3Sendai virusCodon, NonsenseDystrophinKLF4 protein, humanKruppel-Like Factor 4Octamer Transcription Factor-3cell reprogramingDMDDuchenne muscular dystrophyinduced pluripotent stem cells (iPSC)pluripotency

Identifiers

PMID42053710

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.