Evidence map›Paper›PMID 42053707›Full record

ArticleJournal of materials science. Materials in medicine2026

Protective effects of ceria nanoclusters against delayed paraplegia after spinal cord ischemia.

Wang Yang, Ling Zou, Qianqian Wu, Lu Yang, Yonghui Wu, Qingshan Liu, Guangyou Shi, Renqing Jiang, Ying Xia, Jian Sun and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of materials science. Materials in medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Wang Yang *School of Biomedical Engineering and Medical Imaging, Army Medical University, Chongqing, China.
Ling Zou *School of Biomedical Engineering and Medical Imaging, Army Medical University, Chongqing, China.
Qianqian Wu *School of Biomedical Engineering and Medical Imaging, Army Medical University, Chongqing, China.
Lu YangSchool of Biomedical Engineering and Medical Imaging, Army Medical University, Chongqing, China.
Yonghui WuSchool of Biomedical Engineering and Medical Imaging, Army Medical University, Chongqing, China.
Qingshan LiuSchool of Biomedical Engineering and Medical Imaging, Army Medical University, Chongqing, China.
Guangyou ShiSchool of Biomedical Engineering and Medical Imaging, Army Medical University, Chongqing, China.
Renqing JiangArmy Health Service Training Base, Army Medical University, Chongqing, China.
Ying XiaChinese People's Liberation Army Western Theater General Hospital, Chengdu, China.
Jian SunSchool of Biomedical Engineering and Medical Imaging, Army Medical University, Chongqing, China. sunjian@tmmu.edu.cn.
Xiaochao YangSchool of Biomedical Engineering and Medical Imaging, Army Medical University, Chongqing, China. xcyang@tmmu.edu.cn.

Funding

Science and Technology Research Project KJQN202212805
6 · The paper itself

Abstract

Spinal cord ischemia reperfusion injury (SCIRI) induced delayed paraplegia is a complex complication of thoracoabdominal aortic surgery. Reactive oxygen species (ROS) play a critical role in the pathogenesis of delayed paraplegia, suggesting that antioxidants could be a promising therapeutic strategy. Ceria nanomaterials have demonstrated potent antioxidant properties and therapeutic potential in various central nervous system disorders. Herein, the preventive effects of ceria nanoclusters (NCs) against delayed paraplegia were investigated. NCs were synthesized using a facile and green method, incubated with albumin, and exhibited excellent biocompatibility and ROS scavenging activity in vitro, providing neuroprotective effects on neuronal cells. To explore the protective effects against delayed paraplegia in vivo, NCs were intravenously injected into SCIRI rabbits both before ischemia and after reperfusion. Post-reperfusion NCs treatment significantly preserved hindlimb motor function and reduced the incidence of delayed paraplegia. Histopathological and biochemical analyses revealed that NCs protected motor neurons, mitigated oxidative stress, and reduced apoptosis and inflammation in the ischemic spinal cord. These results showed that NCs successfully prevented the development of delayed paraplegia by eliminating excessive ROS.

Indexed as

CeriumParaplegiaSpinal Cord IschemiaAnimalsAntioxidantsApoptosisMaleMotor NeuronsNanoparticlesNeuroprotective AgentsOxidative StressRabbitsReactive Oxygen SpeciesReperfusion InjurySpinal CordAntioxidantsCeriumNeuroprotective AgentsReactive Oxygen Species

Identifiers

PMID42053707
PMCPMC13272265

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.