ArticleMolecular biology reports2026
Macromolecular interactions of recombinant human follicle stimulating hormone (r-hFSH) with piscine FSH receptors enhance reproductive development in Clarias magur: in silico data corroborated by an in vivo study.
Article in Molecular biology reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundFollicle-stimulating hormone (FSH) is a glycoprotein involved in oogenesis and subsequent maturation. An inadequate level of this hormone critically disrupts pre-vitellogenic oocyte progression. This disruption is a major bottleneck in the captive maturation of Asian catfish, Clarias magur. MATERIALS AND
methodsThe current study investigates the potential biological molecular interaction of recombinant human follicle-stimulating hormone (r-hFSH) and FSHR of Clarias magur through comprehensive in silico analysis. Subsequent in vivo research was conducted on the progression of pre-vitellogenic oocytes in Clarias magur by r-hFSH induction and shower simulation consisting of three treatments and one control, viz. C: Control, S: Shower, H: Hormone and SH: Shower and hormone.
resultsThe in silico evaluation revealed that r-hFSH had a better interaction with the C. magur FSH receptor (FSHR) than native FSHβ. These predicted affinity values confirm the trend observed in our docking scores. They provide quantitative support for the conclusion that the recombinant human ligand forms a highly stable complex with the C. magur receptor. In a subsequent 60-day in vivo experiment, weekly r-hFSH administration significantly elevated serum biomarker. Hormone stimulation, with and without shower, effectively advanced oocytes from the pre-vitellogenic stage to spawning. It showed superior fecundity, fertilization, and hatching rates. This demonstrates its potential as a reliable strategy to induce oocyte development and improve captive breeding success in C. magur.
conclusionThe current finding emphasizes a novel opportunity for regulating oogenesis and the advancement of pre-vitellogenic oocyte development to maturation in captive farmed C. magur, utilizing solely r-hFSH.
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