ArticleAging clinical and experimental research2026
Frailty and geriatric complications in older patients with IBD: a nationwide hospital claims database study across Japan.
Article in Aging clinical and experimental research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundOlder patients with inflammatory bowel disease (IBD) often have multimorbidity and functional vulnerability, which increases the risk of in-hospital complications. This study examined whether frailty at admission is associated with hospital-associated geriatric complications in this population.
methodsThis retrospective cohort study was conducted using a nationwide hospital-based claims database in Japan. Patients aged ≥ 60 years hospitalized with ulcerative colitis or Crohn's disease between February 2014 and September 2025 were identified. Frailty was assessed using the Hospital Frailty Risk Score (HFRS ≥ 5). The primary outcome was hospital-associated complications in older people (HAC-OP), which is a composite of functional decline, incontinence, delirium, pressure injury, and falls/fractures. The risk ratios (RRs) and 95% confidence intervals (CIs) were estimated using modified Poisson regression.
resultsAmong 3,905 hospitalizations, 1,220 (31.2%) patients were classified as frail. Overall, 6.7% of hospitalizations were complicated by at least one HAC-OP, with a higher incidence in patients with frailty than in non-frail patients (10.7% vs. 4.8%). Frailty was associated with HAC-OP (adjusted RR 1.74, 95% CI 1.36-2.21), functional decline (adjusted RR 1.54, 95% CI 1.12-2.11), and delirium (adjusted RR 2.50, 95% CI 1.66-3.76). Results were robust in sensitivity analyses using multiple imputation, additional adjustment for length of stay.
conclusionsIn hospitalized older patients with IBD, frailty at admission was associated with hospital-associated geriatric complications, particularly delirium and functional decline. The HFRS may be a useful tool for identifying patients at higher risk, and future studies should evaluate whether frailty-targeted interventions can reduce these complications.
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