Evidence map›Paper›PMID 42053687›Full record

ArticleIntensive care medicine experimental2026

Potential role of extracellular vesicles in bacterial phagocytosis during Escherichia coli pneumonia in ex vivo perfused human lungs.

Hongli He, Shinji Sugita, Qi Hao, Wonjung Hwang, Li Zhou, Yoshifumi Naito, Masaru Shimizu, Sandip Mukherjee, Michael A Matthay, Jae-Woo Lee

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Intensive care medicine experimental, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Hongli He *Department of Critical Care Medicine, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, Sichuan, China.
Shinji Sugita *Departments of Anesthesiology, University of California, Los Angeles, 757 Westwood Plaza Suite 3325, Los Angeles, CA, 90095, USA.
Qi Hao *Departments of Anesthesiology, University of California, Los Angeles, 757 Westwood Plaza Suite 3325, Los Angeles, CA, 90095, USA.
Wonjung HwangDepartments of Anesthesiology, University of California, Los Angeles, 757 Westwood Plaza Suite 3325, Los Angeles, CA, 90095, USA.
Li ZhouDepartments of Anesthesiology, University of California, Los Angeles, 757 Westwood Plaza Suite 3325, Los Angeles, CA, 90095, USA.
Yoshifumi NaitoDepartments of Anesthesiology, University of California, Los Angeles, 757 Westwood Plaza Suite 3325, Los Angeles, CA, 90095, USA.
Masaru ShimizuDepartments of Anesthesiology, University of California, Los Angeles, 757 Westwood Plaza Suite 3325, Los Angeles, CA, 90095, USA.
Sandip MukherjeeDepartments of Anesthesiology, University of California, Los Angeles, 757 Westwood Plaza Suite 3325, Los Angeles, CA, 90095, USA.
Michael A MatthayDepartments of Anesthesiology, Medicine, and Cardiovascular Research Institute, University of California, San Francisco, San Francisco, CA, USA.
Jae-Woo LeeDepartments of Anesthesiology, University of California, Los Angeles, 757 Westwood Plaza Suite 3325, Los Angeles, CA, 90095, USA. jaewoolee@mednet.ucla.edu.ORCID http://orcid.org/0009-0004-9236-9960

Funding

Human Mesenchymal Stem Cell Microvesicles for the Treatment of Acute Lung InjuryR01HL113022 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI LEE, JAE WOO · 2012 to 2020
$4.1M
Therapeutic Use of High Molecular Weight Hyaluronic Acid in Acute Lung Injury Following Severe Bacterial Pneumonia or SepsisR01HL148781 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI ENKHBAATAR, PERENLEI, LEE, JAE WOO · 2020 to 2023
$3.2M
NHLBI NIH HHS 113022NHLBI NIH HHS 134828NHLBI NIH HHS 140026NHLBI NIH HHS 148781NHLBI NIH HHS R01 HL113022NHLBI NIH HHS R01 HL148781Postdoctoral Research Foundation of China 201808510056
6 · The paper itself

Abstract

backgroundPlasma extracellular vesicles (EV) play an inflammatory role in bacterial pneumonia. This study aimed to determine if plasma EVs could be manipulated to reduce lung injury. We hypothesized that inhibition of multidrug resistance-associated protein (MRP) 1 on EVs would increase total leukotriene (LT) B

resultsPlasma EVs released from ex vivo perfused human lungs injured with E.coli bacteria (E.coli EV) or from control lungs (nEV) were incubated with LPS and Reversan, a MRP1 inhibitor, and the effect of EVs on bacterial phagocytosis and inflammation was studied using a macrophage cell line. In addition, the therapeutic effects of Reversan were studied in perfused human lungs injured with E.coli pneumonia. Levels of LTB

conclusionAdministration of a MRP1 inhibitor to plasma EVs increased its LTB

Indexed as

Acute lung injuryBacterial pneumoniaExtracellular vesiclesEx vivo perfused human lungMRP1 inhibitorReversan

Identifiers

PMID42053687
PMCPMC13129058

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.