Evidence map›Paper›PMID 42053647›Full record

ArticleEuropean journal of nutrition2026

Mediating role of lipid metabolism on the association between egg consumption and frailty: results from a large-scale population study.

Jia Qiu, Yinghao Yuchi, Jian Zhang, Xiuli Tang, Xinlai Wang, Huanxiang Zhang, Zhenzhen Tian, Parastou Abbasian, Xiaotian Liu, Jian Hou and 2 more

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Article in European journal of nutrition, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

12 authors.

Jia QiuDepartment of Epidemiology and Biostatistics, College of Public Health, Zhengzhou University, 100 Kexue Avenue, Zhengzhou, 450001, Henan, People's Republic of China.
Yinghao YuchiDepartment of Epidemiology and Biostatistics, College of Public Health, Zhengzhou University, 100 Kexue Avenue, Zhengzhou, 450001, Henan, People's Republic of China.
Jian ZhangDepartment of Epidemiology and Biostatistics, College of Public Health, Zhengzhou University, 100 Kexue Avenue, Zhengzhou, 450001, Henan, People's Republic of China.
Xiuli TangDepartment of Epidemiology and Biostatistics, College of Public Health, Zhengzhou University, 100 Kexue Avenue, Zhengzhou, 450001, Henan, People's Republic of China.
Xinlai WangDepartment of Laboratory Medicine, Hongqi Hospital Affiliated to Mudanjiang Medical University, Mudanjiang, Heilongjiang, People's Republic of China.
Huanxiang ZhangDepartment of Epidemiology and Biostatistics, College of Public Health, Zhengzhou University, 100 Kexue Avenue, Zhengzhou, 450001, Henan, People's Republic of China.
Zhenzhen TianDepartment of Epidemiology and Biostatistics, College of Public Health, Zhengzhou University, 100 Kexue Avenue, Zhengzhou, 450001, Henan, People's Republic of China.
Parastou AbbasianDepartment of Epidemiology and Biostatistics, College of Public Health, Zhengzhou University, 100 Kexue Avenue, Zhengzhou, 450001, Henan, People's Republic of China.
Xiaotian LiuDepartment of Epidemiology and Biostatistics, College of Public Health, Zhengzhou University, 100 Kexue Avenue, Zhengzhou, 450001, Henan, People's Republic of China.
Jian HouDepartment of Epidemiology and Biostatistics, College of Public Health, Zhengzhou University, 100 Kexue Avenue, Zhengzhou, 450001, Henan, People's Republic of China.
Fengling WangDepartment of Epidemiology and Biostatistics, College of Public Health, Zhengzhou University, 100 Kexue Avenue, Zhengzhou, 450001, Henan, People's Republic of China. wangfengling417@163.com.
Chongjian WangDepartment of Epidemiology and Biostatistics, College of Public Health, Zhengzhou University, 100 Kexue Avenue, Zhengzhou, 450001, Henan, People's Republic of China. tjwcj2008@zzu.edu.cn.ORCID http://orcid.org/0000-0001-5091-6621

Funding

Foundation of National Key Program of Research and Development of China 2016YFC0900803Natural Science Foundation of Henan Province 23230042151
6 · The paper itself

Abstract

backgroundEggs as a high-protein food have important impacts on health, but the evidence regarding the relationship between egg consumption and frailty was scarce. The aim of this study was to investigate the association between egg consumption and frailty and to explore the potential mediating pathways.

methodsA total of 23,838 participants were involved from the second wave of the Henan Rural cohort. Data on daily egg consumption frequency were collected through face-to-face interviews using a Food Frequency Questionnaire (FFQ). Frailty was measured by a frailty index consisting of 29 health deficits. Logistic regression models were used to analyse the association between egg consumption and frailty, and dose-response relationships were examined by restricted cubic splines. In addition, mediation effects of lipid metabolism were evaluated.

resultsEach SD increase in egg consumption was associated with a 17% (OR = 0.829, 95% CI: 0.807, 0.853) decrease of prefrailty and a 30% decrease (OR = 0.696, 95% CI: 0.648, 0.747) of frailty. The adjusted ORs and 95% CIs of daily one egg consumption for prefrailty and frailty were 0.577 (0.524,0.637) and 0.380 (0.312, 0.464), respectively. Additionally, egg consumption exhibited a nonlinear dose-response relationship with frailty. TG and HDL-C partially mediated 24.9% and 8.6% of the estimated association between egg intake and prefrailty risk.

conclusionModerate egg consumption was associated with a lower risk of frailty. TG and HDL-C may play partial mediating roles in the association. It suggests that egg consumption may be an effective strategy for preventing frailty.

trial registrationThe Henan Rural Cohort Study has been registered at Chinese Clinical Trial Register (Registration number: ChiCTR-OOC-15006699). Date of registration: 06 July, 2015. http://www.chictr.org.cn/showproj.aspx?proj=11375 .

Indexed as

DietEggsFrail ElderlyFrailtyLipid MetabolismAgedChinaCohort StudiesFemaleHumansLogistic ModelsMaleMiddle AgedSurveys and QuestionnairesEgg consumptionFrailtyPrefrailtyRural population

Identifiers

PMID42053647

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.