ArticleJournal of virology2026
Pvf/Pvr signaling relieves white spot syndrome virus-induced lipid consumption to inhibit viral infection in shrimp.
Article in Journal of virology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Platelet-derived growth factor (PDGF) and vascular endothelial growth factor (VEGF)-related factors (Pvfs) are highly conserved and widespread growth factors whose signaling is mediated by the PDGF/VEGF-related receptor (Pvr). Pvf/Pvr signaling is involved in the regulation of development, immunity, and metabolism of organisms and can be a key therapeutic target for a variety of clinical diseases. However, the functions and mechanisms of Pvf/Pvr signaling in viral infections are largely unknown. In the present study, we found that Pvf/Pvr family members, MjPvf2/MjPvr3, inhibit white spot syndrome virus (WSSV) infection by regulating lipid metabolism in the kuruma shrimp ( IMPORTANCE: Viral infection affects host lipid metabolism. This process depletes the host's lipids to support viral replication. Pvf/Pvr signaling is widely involved in host physiological processes, but its role in viral infection has not been clarified. We demonstrate that Pvf/Pvr signaling exerts an antiviral effect by relieving the lipid consumption caused by white spot syndrome virus (WSSV) infection in shrimp. This study provides new insights into the effects of Pvf/Pvr signaling on antiviral immunity and highlights the complexity of lipid metabolism under WSSV infection.
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