ArticleJournal of neuromuscular diseases2026
Predictors of relapses in patients with chronic inflammatory demyelinating polyneuropathy receiving subcutaneous immunoglobulin therapy - a post-hoc analysis.
Article in Journal of neuromuscular diseases, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundIn a previous study we demonstrated that standardized tapering off subcutaneous immunoglobulin (SCIG) is a safe way to identify remission in patients with chronic inflammatory demyelinating polyneuropathy (CIDP). However, clinical characteristics and dosage of SCIG in patients in remission are unknown.
methodsIn the present study, we aimed to identify characteristics of patients in remission during tapering off SCIG. Participants received a stable SCIG dosage and followed a standardized tapering off regimen providing 90%, 75%, 50%, 25% and 0% of the initial dose, every 12
resultsReceiving a dosage of SCIG >25 g/week predicts a higher risk of relapse, OR 6.3 (95CI 1.8-20.2)(p = 0.004), but not when considering body weight (SCIG >0.3 g/kg/week), OR 3.3 (95CI 1.0-9.7)(p = 0.05). Moreover, a higher level of serum NfL OR 8.2 (95CI 1.1-93.3)(p = 0.04) predicts relapse. Low scores on EQ-5D-5L at baseline predicted increased risk of relapse. Serum calprotectin was similar in patients with relapse and in remission. Evaluating measurements from baseline, final visit and the last visit before final visit (LVBF), we found that deterioration in clinical performance could not be predicted at LVBF based on any of the tests performed.
conclusionPatients experiencing a relapse of CIDP during tapering off SCIG seem to receive a total higher dosage of immunoglobulin and had a higher sNfL prior to tapering off compared to patients without a relapse.
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