Enantioselective Pyrazole Alkylation via Iridium and Squaramide Catalyzed N-H Insertion.

Kirsten J Ruud, Antoinette J Antonucci, Veljko Lukovic, Andrew Vennemeyer, Vy M Dong

Abstract read

In one paragraph

Article in Journal of the American Chemical Society, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Kirsten J RuudDepartment of Chemistry, University of California, Irvine, Irvine, California 92697, United States.

Antoinette J AntonucciDepartment of Chemistry, University of California, Irvine, Irvine, California 92697, United States.ORCID 0000-0003-2505-1667

Veljko LukovicDepartment of Chemistry, University of California, Irvine, Irvine, California 92697, United States.

Andrew VennemeyerDepartment of Chemistry, University of California, Irvine, Irvine, California 92697, United States.ORCID 0009-0001-8026-4617

Vy M DongDepartment of Chemistry, University of California, Irvine, Irvine, California 92697, United States.ORCID 0000-0002-8099-1048

Funding

Innovative Tools for Chemical Synthesis: Metal-Hydride Catalysis, Medicinal Motifs, and Molecular ProbesR35GM127071 · NIGMS · UNIVERSITY OF CALIFORNIA-IRVINE · PI Vy M Dong · 2018 to 2026

$4.9M

NIGMS NIH HHS R35 GM127071

6 · The paper itself

Abstract

While pyrazoles are privileged scaffolds in medicinal chemistry, their tautomerization and Lewis-basicity pose challenges for enantioselective catalytic alkylation. Here, we report an iridium and squaramide catalyzed N-H insertion that provides a site-selective and enantioselective route to α-pyrazole esters. An Ir catalyst promotes site-selective insertion at the less sterically hindered nitrogen (N

Identifiers

PMID42053177

DOI10.1021/jacs.6c00508

PMCPMC13242524

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.