ArticleRevista de neurologia2026
Association of MOCA Cognitive Domains and Serum Biomarkers With Anxiety Disorders in Elderly Men With Cognitive Impairment: A Cross-Sectional Analysis.
Article in Revista de neurologia, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
backgroundAnxiety symptoms in elderly patients with cognitive impairment (CI) often reflect shared neurobiological processes rather than distinct psychiatric disorders. Current diagnostic approaches lack objective biomarkers for early identification. This study investigated the association between serum biomarkers and anxiety disorder status in elderly men with CI and to evaluate the exploratory discriminative ability of cognitive domains and biomarker profiles in differentiating CI patients with and without comorbid anxiety.
methodsThis cross-sectional retrospective study analyzed 86 elderly male CI patients (Group A: CI alone, n = 41; Group B: CI with anxiety, n = 45) at Jiangsu Rongjun Hospital (June-December, 2024). Anxiety disorder diagnosis was established through structured clinical interviews based on the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5) criteria conducted by two independent psychiatrists, with the Hamilton Anxiety Scale (HAMA) serving as an initial severity screening instrument. The Montreal Cognitive Assessment (MOCA) was used to evaluate cognitive function. Enzyme-linked immunosorbent assay (ELISA) was used to measure serum Tau protein (Tau), β-amyloid (Aβ), visinin-like protein 1 (VILIP-1), malondialdehyde (MDA), tumor necrosis factor-α (TNF-α), and interleukin-6 (IL-6); reverse transcription-polymerase chain reaction (RT-PCR) quantified microRNA-34c (
resultsGroup B showed worse cognitive performance across the MOCA domains, with attention (area under the curve [AUC] = 0.738) and delayed recall (AUC = 0.742) demonstrating the strongest discriminative ability. Biomarker analysis revealed elevated Tau (AUC = 0.957), MDA (AUC = 0.941), and VILIP-1 (AUC = 0.914) in anxiety patients. Within-group analyses showed that anxiety severity correlated negatively with MiR-34c and positively with Tau, Aβ, MDA, IL-6, and VILIP-1. Under the Bonferroni-adjusted threshold (
conclusionCombined cognitive assessment (attention, delayed recall) and serum biomarkers (Tau, MDA, VILIP-1, MiR-34c) demonstrate promising discriminative ability for identifying anxiety in elderly male patients with CI. These findings are exploratory and derived from a single-center cohort of retired male military veterans with pronounced baseline group imbalances, which substantially limits generalizability to the broader elderly CI population. The identified markers may reflect shared neuroinflammatory and oxidative stress pathways underlying both cognitive and emotional dysfunction, warranting further investigation as potential targets for integrated therapeutic approaches. Validation in prospective, multicenter, sex-inclusive cohorts with balanced comparison groups is essential before any clinical application can be considered.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.