Trial reportRevista de neurologia2026
Efficacy and Neurophysiological Mechanisms of 10 Hz Repetitive Transcranial Magnetic Stimulation for Post-Stroke Dysphagia: A Randomized Controlled Trial.
Trial report in Revista de neurologia, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Authors and funding
7 authors.
Funding
Abstract
backgroundPost-stroke dysphagia (PSD) is a common and serious complication, yet conventional rehabilitation therapies have limited efficacy. Repetitive transcranial magnetic stimulation (rTMS) is a promising treatment, but its optimal intervention strategy remains undetermined.
methodsSeventy-five PSD patients were randomly assigned in a 1:1:1 ratio to the sham rTMS group, affected rTMS group and bilateral rTMS group. All groups received the corresponding rTMS intervention and conventional rehabilitation therapy. Swallowing function was assessed at baseline (T0) and after treatment (T1) using the standardized swallowing assessment (SSA), penetration-aspiration scale (PAS), yale pharyngeal residue severity rating scale (YPR-SRS), and suprahyoid motor evoked potentials (MEP). Adverse reactions and dropouts were recorded.
resultsAfter treatment, the SSA scores of all three groups were significantly improved. Bilateral rTMS showed significantly greater improvement in SSA and a higher treatment response rate (77.27%) compared to both the sham group and the affected rTMS group (
conclusionsConventional rehabilitation combined with 10 Hz rTMS targeting the swallowing cortex can effectively improve swallowing function in PSD patients. Bilateral rTMS is a superior strategy. Its therapeutic advantage may stem from the synergistic modulation of bilateral cortical excitability and neural conduction efficiency, providing a better multi-target neuromodulation option for clinical practice. CLINICAL
trial registrationNo: ChiCTR2300068730. https://www.chictr.org.cn/showproj.html?proj=182568.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.