Evidence map›Paper›PMID 42052727›Full record

ArticleExperimental physiology2026

Glycosylation of the murine cardiac channel TRPM4 is altered by the pathogenic p.I376T variant.

Sabrina Guichard, Emanuele di Lorenzo, Dominic Schneiter, Maria Essers, Prakash Arullampalam, Jean-Sébastien Rougier, Hugues Abriel

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Experimental physiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Sabrina GuichardInstitute of Biochemistry and Molecular Medicine, University of Bern, Bern, Switzerland.
Emanuele di LorenzoInstitute of Biochemistry and Molecular Medicine, University of Bern, Bern, Switzerland.
Dominic SchneiterInstitute of Biochemistry and Molecular Medicine, University of Bern, Bern, Switzerland.
Maria EssersInstitute of Biochemistry and Molecular Medicine, University of Bern, Bern, Switzerland.
Prakash ArullampalamInstitute of Biochemistry and Molecular Medicine, University of Bern, Bern, Switzerland.
Jean-Sébastien RougierInstitute of Biochemistry and Molecular Medicine, University of Bern, Bern, Switzerland.ORCID https://orcid.org/0000-0002-8710-0260
Hugues AbrielInstitute of Biochemistry and Molecular Medicine, University of Bern, Bern, Switzerland.ORCID https://orcid.org/0000-0003-0465-5138

Funding

Swiss National Science Foundation 310030_215274
6 · The paper itself

Abstract

TRPM4 is a calcium-activated, voltage-modulated, non-selective cation channel expressed in various tissues, including the heart. In 2016, we reported on a large French family with progressive heart block type I carrying the variant TRPM4 p.I376T. In the present study, the aim was to investigate the consequence of the channel variant TRPM4 p.I376T in cardiac physiology in a newly generated Trpm4 knock-in mouse line. Male and female Trpm4 knock-in (Trpm4

Indexed as

TRPM Cation ChannelsAnimalsElectrocardiographyFemaleGene Knock-In TechniquesGlycosylationHeart BlockMaleMiceMice, Inbred C57BLMyocardiumMyocytes, CardiacPatch-Clamp TechniquesTRPM4 protein, mouseTRPM Cation Channelscardiac electrophysiologymurine knock‐in modelTRPM4 channel

Identifiers

PMID42052727
PMCPMC13327340

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.