Evidence map›Paper›PMID 42052607›Full record

ArticleCaspian journal of internal medicine2026

Diagnostic performance of thrombin generation assay in patients with acute myocardial infarction.

Omid Reza Zekavat, Mohammad Shojaie, Hoda Sezavarian, Sonia Rostami Ghorbani, Seyed Javad Dehghani, Javad Gerdabi, Peyman Izadpanah, Shirin Parand, Sezaneh Haghpanah

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Article in Caspian journal of internal medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Omid Reza ZekavatHematology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
Mohammad ShojaieCardiology Department, Research Center of Non-Communicable Diseases, Jahrom University of Medical sciences, Jahrom, Iran.
Hoda SezavarianHematology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
Sonia Rostami GhorbaniCardiology Department, Research Center of Non-Communicable Diseases, Jahrom University of Medical sciences, Jahrom, Iran.
Seyed Javad DehghaniNeshat Laboratory Research Center, Shiraz, Iran.
Javad GerdabiNeshat Laboratory Research Center, Shiraz, Iran.
Peyman IzadpanahCardiology Department, Shiraz University of Medical Sciences, Shiraz, Iran.
Shirin ParandHematology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
Sezaneh HaghpanahHematology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Thrombin generation (TG) assays have been developed to assess the overall coagulability of blood, as thrombin plays a pivotal role in hemostasis and thrombosis. Although increased TG has been associated with acute myocardial infarction (MI) in some previous reports, the results have been inconsistent. This study aimed to evaluate TG in platelet-poor plasma specimens from patients with confirmed acute MI. Methods: In this case-control study, we enrolled a total of 50 patients diagnosed with acute MI using convenience sampling, along with 50 healthy individuals. TG assays were performed in both groups, and the calculated TG indices were compared. Results: Forty-one patients with confirmed acute MI (24 males, 17 females; mean age 62.7±14.9 years) and 50 healthy controls (40 males, 10 females; mean age 57.5±12.9) were included in the analysis. TG assay indices were not significantly different in acute MI patients compared to healthy subjects (p >0.05). In terms of the diagnostic utility of TG assays, a five-variable panel yielded an AUC of 0.659 [95% CI: 0.547-0.770, P=0.010], with a sensitivity of 65.9% and specificity of 62% for identifying acute MI. Conclusion: All TG parameters taken together appear to have a predictive value in detecting acute MI. However, further studies with larger sample sizes are needed to confirm this finding.

Indexed as

AtherothrombosisCoagulationEndogenous Thrombin PotentialMyocardial infarctionThrombin generation

Identifiers

PMID42052607
PMCPMC13112114

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