ArticleCaspian journal of internal medicine2026
Acromegalic features and hypoglycemia: Doege-Potter syndrome.
Article in Caspian journal of internal medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Doege-Potter syndrome (DPS) is a condition characterized by severe, symptomatic, and sustained hypoglycemia, refractory to medical treatment, due to non-insular tumor cells. Case Presentation: We describe the case of a 73-year-old male with acromegalic features and two months of hypoglycemic episodes, in whom a giant mass was identified in the right hemithorax via radiography. Surgical resection of the tumor resolved hypoglycemia and improved the acromegalic traits.Solitary fibrous tumors (SFTs) are rare neoplasms that predominantly affect individuals aged 50 to 60 years. Doege-Potter syndrome is a cause of hypoglycemia, present in 2-4% of SFT cases. Its manifestations arise from abnormal synthesis and secretion of insulin-like growth factor (IGF)-2 by the SFT. In rare instances, patients with DPS may exhibit signs of acromegaly, attributed to the stimulation of the IGF-1 receptor by IGF-2. The initial diagnostic approach to DPS includes imaging and hormonal studies, while the definitive diagnosis is made through histopathology. Conclusions: We emphasize the importance of considering DPS in patients with thoracic tumors and persistent hypoglycemia, especially when accompanied by acromegalic features.
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