Evidence map›Paper›PMID 42052494›Full record

ArticleFrontiers in oncology2026

Histotripsy treatment reduces tumor burden and extends survival in an orthotopic mouse model of osteosarcoma.

Elliana R Vickers, Alayna N Hay, Victor A Lopez, Lauren N Ruger, Ny T C Luong, Julianna M Diodato, Triniti Antony Baskar, Alyssa Sze, Maosen Wang, Steven B Soliman and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Elliana R VickersVirginia Tech Animal Cancer Care and Research Center, Virginia-Maryland College of Veterinary Medicine, Roanoke, VA, United States.
Alayna N HayVirginia Tech Animal Cancer Care and Research Center, Virginia-Maryland College of Veterinary Medicine, Roanoke, VA, United States.
Victor A LopezDepartment of Biomedical Engineering and Mechanics, Virginia Polytechnic Institute and State University, Blacksburg, VA, United States.
Lauren N RugerDepartment of Biomedical Engineering and Mechanics, Virginia Polytechnic Institute and State University, Blacksburg, VA, United States.
Ny T C LuongVirginia Tech Animal Cancer Care and Research Center, Virginia-Maryland College of Veterinary Medicine, Roanoke, VA, United States.
Julianna M DiodatoSchool of Neuroscience, Virginia Polytechnic Institute and State University, Blacksburg, VA, United States.
Triniti Antony BaskarDepartment of Biological Sciences, Virginia Polytechnic Institute and State University, Blacksburg, VA, United States.
Alyssa SzeVirginia Tech Carillion School of Medicine, Virginia Polytechnic Institute and State University, Roanoke, VA, United States.
Maosen WangFralin Biomedical Research Institute, Virginia Polytechnic Institute and State University, Roanoke, VA, United States.
Steven B SolimanDivision of Musculoskeletal Radiology, Department of Radiology, University of Michigan/Michigan Medicine, Ann Arbor, MI, United States.
Gunjan B MalhotraDivision of Musculoskeletal Radiology, Department of Radiology, University of Michigan/Michigan Medicine, Ann Arbor, MI, United States.
Sheryl Coutermarsh-OttDepartment of Biomedical Sciences and Pathobiology, Virginia-Maryland College of Veterinary Medicine, Blacksburg, VA, United States.
John H RossmeislDepartment of Biomedical Sciences and Pathobiology, Virginia-Maryland College of Veterinary Medicine, Blacksburg, VA, United States.
Eli VlaisavljevichDepartment of Biomedical Engineering and Mechanics, Virginia Polytechnic Institute and State University, Blacksburg, VA, United States.
Joanne TuohyVirginia Tech Animal Cancer Care and Research Center, Virginia-Maryland College of Veterinary Medicine, Roanoke, VA, United States.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Osteosarcoma (OS) is a devastating primary bone tumor. Histotripsy, a non-invasive ablation modality that mechanically destroys tissue with focused ultrasound, has shown promise for the treatment of OS. The goal of this study is to characterize the ablative effects after histotripsy treatment in an orthotopic mouse model of OS. Methods: Mice (n=53) were grouped based on tumor volume on the day of histotripsy treatment: treated-small (<200 mm Results: At 1 DPT, treated tumors show significant hemorrhage (p < 0.0001), loss of contrast enhancement (34% decrease, Conclusions: Histotripsy treatment significantly reduced tumor burden and extended survival compared to untreated controls. These results highlight histotripsy's promise as a safe and effective non-invasive treatment for OS.

Indexed as

ablationbone tumorfocused ultrasoundhistotripsymouseorthotopicosteosarcomarodent

Identifiers

PMID42052494
PMCPMC13111011

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.