ArticleFrontiers in oncology2026
Isolated primary pericardial sarcomatoid mesothelioma: a case report.
Article in Frontiers in oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Primary pericardial mesothelioma is an exceedingly rare malignancy, often diagnosed late due to nonspecific clinical and radiologic findings. We report a case of isolated pericardial mesothelioma progressing from mesothelioma Case presentation: A 58-year-old male with a remote history of Hodgkin's lymphoma (previously treated with chemotherapy and mediastinal radiotherapy) presented with progressive dyspnoea, orthopnoea, and recurrent pericardial and left pleural effusions. Initial diagnostic video-assisted thoracoscopic surgery (VATS) with mini-thoracotomy revealed densely adherent pericardium, intra-pericardial clots, and 1.5L of blood-stained pleural fluid. Histology demonstrated a sparse population of surfcatypical mesothelial proliferation with methylthioadenosine phosphorylase (MTAP) loss and retained BRCA1-associated protein 1 (BAP1). There was no invasive growth and therefore, the appearance for concerning for mesothelioma Conclusion: This case highlights the importance of early diagnostic suspicion in patients with prior mediastinal irradiation who present with recurrent pericardial effusions or evolving constrictive physiology. While pericardiectomy remains the standard of care for constriction regardless of etiology, the diagnosis of mesothelioma-particularly sarcomatoid subtype-warrants timely intervention. Early recognition of pre-invasive histological changes may offer a critical opportunity for curative resection before progression to aggressive disease.
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