ArticleFrontiers in oncology2026
Comprehensive profiling of alternative splicing and immune landscapes in rectal cancer: implications for mRNA vaccine design and immune subtype stratification.
Article in Frontiers in oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: mRNA vaccines have emerged as a promising platform for cancer immunotherapy, particularly following the success of COVID-19 vaccines. However, the development of cancer vaccines presents challenges such as difficulties in antigen prediction and poor immunogenicity, especially in identifying and delivering highly immunogenic tumor-specific antigens. The variability and low immunogenicity of tumor antigens further complicates this process. Methods: This study utilized public data and bioinformatics analysis to identify potential tumor antigens in cancer and characterize different immune subtypes. This approach aims to guide the development of cancer mRNA vaccines with enhanced immune response. Results: In the cancer genome atlas rectal adenocarcinoma(TCGA-READ), Exon skipping was the most common alternative splicing event in TCGA-READ, whereas mutually exclusive exons were the least common. We identified 4480 upregulated and 3328 downregulated AS events, with missense mutations being the most frequent. A total of 217 potential antigen genes were identified by intersecting upregulated AS anomalies and frameshift mutations. Conclusions:
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