Evidence map›Paper›PMID 42052332›Full record

ArticleMedical hypotheses2025

Calcitonin Gene-Related Peptide-Induced Central Sensitization: A Hypothesis for Long COVID Symptoms.

Ella J Lee, Cynthia Tsang, Martha Lucía Gutiérrez Pérez, Mehdi Abouzari, Hamid R Djalilian

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Medical hypotheses, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Ella J LeeDepartment of Otolaryngology-Head and Neck Surgery, University of California, Irvine, USA.
Cynthia TsangDepartment of Otolaryngology-Head and Neck Surgery, University of California, Irvine, USA.
Martha Lucía Gutiérrez PérezDepartment of Otolaryngology-Head and Neck Surgery, University of California, Irvine, USA.
Mehdi AbouzariDepartment of Otolaryngology-Head and Neck Surgery, University of California, Irvine, USA.
Hamid R DjalilianDepartment of Otolaryngology-Head and Neck Surgery, University of California, Irvine, USA.

Funding

University of California Health Participation in the National COVID Cohort Collaborative (N3C)UL1TR001414 · NCATS · UNIVERSITY OF CALIFORNIA-IRVINE · PI COOPER, DAN M, VILAIN, ERIC J. · 2015 to 2023
$35.1M
Institute for Clinical and Translational ScienceUM1TR004927 · NCATS · UNIVERSITY OF CALIFORNIA-IRVINE · PI DAN M COOPER, Eric J. Vilain · 2024 to 2026
$12.2M
NRSA Training CoreTL1TR001415 · NCATS · UNIVERSITY OF CALIFORNIA-IRVINE · PI CAIOZZO, VINCENT JAMES, HEAD, ELIZABETH · 2015 to 2023
$4.2M
NCATS NIH HHS TL1 TR001415NCATS NIH HHS UL1 TR001414NCATS NIH HHS UM1 TR004927
6 · The paper itself

Abstract

Central sensitization (CS) denotes aberrant processing of sensory stimuli within the central nervous system, wherein innocuous inputs activate pain pathways, leading to pain hypersensitivity. Features observed in CS conditions are often present in patients with long COVID, suggesting a potentially shared pathophysiological mechanism. We hypothesize that elevated levels of calcitonin gene-related peptide (CGRP), a neuropeptide known to play an integral role in the development of CS, may contribute to the persistent symptoms observed in long COVID. This article explores the role of CGRP within the context of CS and proposes its potential relationship to long COVID.

Indexed as

Central SensitizationCGRPLong COVIDMigraineSARS-CoV-2

Identifiers

PMID42052332
PMCPMC13120763

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.