ArticleStructural heart : the journal of the Heart Team2026
Sex and Racial Disparities in Outcomes of Transcatheter Edge-to-Edge Mitral Valve Repair for Functional Mitral Regurgitation: A Multicenter Prospective Analysis.
Article in Structural heart : the journal of the Heart Team, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Functional mitral regurgitation (FMR) is associated with poor heart failure (HF) outcomes. Mitral transcatheter edge-to-edge repair (M-TEER) is recommended for symptomatic patients despite medical therapy, though the influence of sex and race on outcomes remains understudied. Methods: We analyzed Society of Thoracic Surgeons/American College of Cardiology Transcatheter Valve Therapeutics registry data on patients undergoing M-TEER for FMR (November 2013 to December 2021). Primary outcomes were 30-day and 12-month all-cause and HF hospitalizations and mortality. Cox models adjusted for demographic and clinical variables. Results: A total of 9441 patients were enrolled (57.4% male; 80.4% White, 16.3% Black, 2.7% Asian). Black patients were younger, had lower left ventricular (LV) ejection fraction, and had larger LV dimensions compared to White patients. They experienced lower 30-day procedural success rates (48.9% vs. 57.0%; Conclusions: Racial and sex disparities in M-TEER outcomes are evident. Black patients present with more advanced disease and experience lower procedural success and higher 12-month HF readmission rates compared to White. Female patients demonstrate lower procedural success but similar long-term adjusted outcomes compared to males. Efforts to address these disparities are essential to improving outcomes for all FMR patients.
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