ArticleFrontiers in bioengineering and biotechnology2026
Preoperative of balloon pulmonary angioplasty in chronic thromboembolic pulmonary hypertension using virtual balloon expansion: a pilot study.
Article in Frontiers in bioengineering and biotechnology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objectives: Chronic thromboembolic pulmonary hypertension (CTEPH) demands precise balloon pulmonary angioplasty (BPA) planning to address unpredictable hemodynamic outcomes. This pilot study explores the potential of virtual simulation to inform this process. Methods: We developed two virtual BPA (vBPA) approaches for patient-specific computational fluid dynamics (CFD) models derived from preoperative computed tomography pulmonary angiography (CTPA) scans of three CTEPH cases featuring right-lung lesion dominant: vBPA1 for morphology-restoring dilation and vBPA2 for rigid homogeneous dilation. We simulated interventions on 28 vascular regions, generating 336 hemodynamic comparisons quantified via Euclidean distance and a composite score integrating multiple spatial metrics. The Euclidean distance value or composite score represents deviation from virtual POST. Results: Our analysis suggested a complex relationship between pulmonary vascular resistance (PVR) and vortex dynamics. The vBPA simulations indicated a temporal decoupling in hemodynamic response, where initial PVR improvement could coincide with an intensification of high-helicity vortices, potentially associated with subsequent hemodynamic rebound as observed in one patient. Preliminary trends hinted at differential performance of the vBPA methods across lesion types. vBPA2 (rigid dilation) showed relatively lower composite scores for web lesions (composite scores: 0.176-0.220 vs. vBPA1: 0.239-0.262), while vBPA1 (morphology-restoring) produced a relatively lower score for the ring-like stenosis (composite score: 0.168 vs. vBPA2: 0.190). Conclusion: This pilot study presents a computational pipeline that bridges anatomical imaging with simulated hemodynamics for personalized BPA planning. The observed trends suggest that lesion morphology may influence the suitability of different virtual planning strategies. This work provides preliminary insights and a methodological foundation for future validation in larger cohorts aimed at enhancing personalized BPA planning for CTEPH.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.