Evidence map›Paper›PMID 42052289›Full record

ArticleOpen forum infectious diseases2026

Advancing Antimicrobial Stewardship With Diagnostic Excellence: The Role of Bayesian Reasoning.

Ephraim L Tsalik, Neha K Prasad, Lee A Fleisher

Abstract read
In one paragraph

Article in Open forum infectious diseases, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Ephraim L TsalikAdjunct Associate Professor of Medicine, Duke University School of Medicine, Durham, North Carolina, USA.ORCID https://orcid.org/0000-0002-6417-2042
Neha K PrasadRubrum Advising, Bala Cynwyd, Pennsylvania, USA.ORCID https://orcid.org/0000-0003-4635-3795
Lee A FleisherRubrum Advising, Bala Cynwyd, Pennsylvania, USA.ORCID https://orcid.org/0000-0003-2899-2294

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Antimicrobial resistance and inappropriate antibiotic use are urgent threats to global health and patient safety. Early antibiotic prescribing often occurs despite uncertain infection status, leading to unnecessary exposure and contributing to resistance. This article advocates for strengthening antimicrobial stewardship by integrating diagnostic stewardship and Bayesian reasoning to more explicitly consider disease probability in clinical decisions. In particular, probability thresholds should be included in clinical guidelines to inform testing decisions that may prompt antibiotic initiation. We provide several clinical examples and highlight the need for clinician education in Bayesian reasoning, underpinned by real-time decision support tools. Anchoring clinical practice in probability-based frameworks promises to refine antibiotic prescribing, enhance patient safety outcomes, and curb the progression of antimicrobial resistance.

Indexed as

bacterial vaginosisBayes theoremClostridioides difficilediagnosispolymerase chain reactionsepsis

Identifiers

PMID42052289
PMCPMC13112427

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.