Evidence map›Paper›PMID 42052240›Full record

ArticleResearch square2026

Autophagy-related protein 1 orchestrates autophagy initiation and feedback degradation in Alternaria alternata.

Celine Yen Ling Choo, Hsin-Yu Lu, Kuang-Ren Chung, Pei-Ching Wu

Abstract readPreprint
In one paragraph

Article in Research square, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors.

Celine Yen Ling ChooNational Chung Hsing University.
Hsin-Yu LuNational Chung Hsing University.
Kuang-Ren ChungNational Chung Hsing University.
Pei-Ching WuChina Medical University.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Autophagy plays an essential role in fungal development and stress adaptation, yet its regulatory mechanisms in filamentous fungi remain incompletely understood. We functionally characterized Results: Deletion of Conclusions: These findings reveal a noncanonical feedback mechanism in which AaAtg8 facilitates AaAtg1 degradation to modulate autophagic output. Our study elucidates the structure-function relationship of AaAtg1 and uncovers a dual regulatory mechanism that coordinates autophagy progression and stress adaptation in the plant-pathogenic fungus.

Indexed as

AIMAutophagic flux regulationFungal pathogenicityNutrient sensingOxidative stress tolerancePeroxisome turnover

Identifiers

PMID42052240
PMCPMC13119307

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.