ArticleRSC advances2026
Syntheses, DNA interactions, and photodynamic antimicrobial properties of near-infrared indolium carbocyanine dyes.
Article in RSC advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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5 authors.
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Abstract
This study describes the design, syntheses, and evaluation of two new near-infrared (NIR) carbocyanine dyes as candidate photosensitizing agents for antimicrobial photodynamic therapy (aPDT). In aPDT, light activates photosensitizers to produce cytotoxic reactive oxygen species (ROS), to remediate treatment-resistant microbial infections. The carbocyanines feature terminal indolium groups connected by a heptamethine chain, enabling absorption of light in the tissue-penetrating NIR region. They also incorporate strategically positioned halogen atoms for improving hydrophobicity, chemical stability, and triplet-state yields. To enhance interactions with negatively charged bacterial cell walls and DNA, the dyes have different net charges at pH 7.0 (+1
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