ArticleRSC advances2026
Design, synthesis, and enzyme kinetic evaluation of oxadiazole derivatives as nucleoside triphosphate diphosphohydrolase (NTPDase) inhibitors: an integrated
Article in RSC advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Given the pivotal function of ecto-nucleoside triphosphate diphosphohydrolases (ecto-NTPDases) in cancer progression and purinergic signaling, the identification of potential small heterocyclic inhibitors has become a significant objective in medicinal chemistry campaigns. This study concentrated on the development of substituted oxadiazole derivatives as ecto-NTPDase inhibitors. A series of 1,3,4-oxadiazole derivatives (4, 7a-7g) were synthesized and assessed for their
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