Evidence map›Paper›PMID 42052100›Full record

ArticleDrug design, development and therapy2026

Biomarker Variants of Dopamine Receptor Genes Influence the Binding Interaction Between Dopamine Receptor and Risperidone.

Noor B Almandil, Sayed AbdulAzeez, Mohamed S Gomaa, Abdallah M Ibrahim, Sherlin John John, Selvaraj Prathas, Tharmathass Stalin Dhas, Jesu Francis Borgio

Abstract read
In one paragraph

Article in Drug design, development and therapy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Noor B AlmandilDepartment of Clinical Pharmacy Research, Institute for Research and Medical Consultations (IRMC), Imam Abdulrahman Bin Faisal University, Dammam, 31441, Saudi Arabia.
Sayed AbdulAzeezDepartment of Genetic Research, Institute for Research and Medical Consultations (IRMC), Imam Abdulrahman Bin Faisal University, Dammam, 31441, Saudi Arabia.ORCID 0000-0002-9763-9446
Mohamed S GomaaDepartment of Pharmaceutical Chemistry, College of Clinical Pharmacy, Imam Abdulrahman Bin Faisal University, Dammam, 31441, Saudi Arabia.ORCID 0000-0003-2112-9092
Abdallah M IbrahimDepartment of Fundamentals of Nursing, College of Nursing, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia.
Sherlin John JohnDepartment of Zoology, Entomology Research Unit (ERU), St. Xavier's College (Autonomous), Palayamkottai, Affiliated to Manonmaniam Sundaranar University, Tirunelveli, Tamil Nadu, India.ORCID 0000-0001-8470-3915
Selvaraj PrathasDepartment of Zoology, Entomology Research Unit (ERU), St. Xavier's College (Autonomous), Palayamkottai, Affiliated to Manonmaniam Sundaranar University, Tirunelveli, Tamil Nadu, India.
Tharmathass Stalin DhasNational Facility for Coastal and Marine Research, Centre for Ocean Research (DST- FIST Sponsored Centre), Sathyabama Institute of Science and Technology, Chennai, 600119, Tamil Nadu, India.
Jesu Francis BorgioDepartment of Genetic Research, Institute for Research and Medical Consultations (IRMC), Imam Abdulrahman Bin Faisal University, Dammam, 31441, Saudi Arabia.ORCID 0000-0001-7199-1540

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Risperidone is atypical antipsychotic medication commonly used to control behavioral symptoms in children with autism and widely considered a first-line treatment for acute and maintenance treatment of schizophrenia and bipolar mania. However, the response to risperidone is varied between patients due to genetic factors such as dopamine receptor genes. Methods: Using state-of-the-art tools, the current study designed to predict the most deleterious SNPs of the five ( Results: The analysis predicted the most deleterious nsSNPs in each dopamine receptor: rs759268810 in Conclusion: The observation of the state-of-the-art tools-based analysis and observations of MD simulations prioritized the F198C of

Indexed as

Antipsychotic AgentsReceptors, DopamineRisperidoneBiomarkersHumansPolymorphism, Single NucleotideProtein BindingAntipsychotic AgentsBiomarkersReceptors, DopamineRisperidoneautismbipolar maniadockingdopamine receptorDRD2mutationrisperidoneschizophrenia

Identifiers

PMID42052100
PMCPMC13117852

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.