Evidence map›Paper›PMID 42051982›Full record

ArticleChemical science2026

Target-agnostic SAR mapping and immunological evaluation of (-)-FR252921 and analogs against primary human immune cells.

Iakovos Saridakis, Manuel Schupp, Haoqi Zhang, Thomas Leischner, Laura Marie Gail, Konstantin Günther, Martina Drescher, Florian Doubek, Daniel Kaiser, Georg Stary and 1 more

Abstract read
In one paragraph

Article in Chemical science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Iakovos SaridakisInstitute of Organic Chemistry, University of Vienna Währinger Straße 38 1090 Vienna Austria nuno.maulide@univie.ac.at.ORCID https://orcid.org/0000-0002-2690-5401
Manuel SchuppInstitute of Organic Chemistry, University of Vienna Währinger Straße 38 1090 Vienna Austria nuno.maulide@univie.ac.at.ORCID https://orcid.org/0000-0001-5459-4922
Haoqi ZhangInstitute of Organic Chemistry, University of Vienna Währinger Straße 38 1090 Vienna Austria nuno.maulide@univie.ac.at.ORCID https://orcid.org/0009-0004-4174-5380
Thomas LeischnerInstitute of Organic Chemistry, University of Vienna Währinger Straße 38 1090 Vienna Austria nuno.maulide@univie.ac.at.
Laura Marie GailCeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences Lazarettgasse 14, AKH BT 25.3 1090 Vienna Austria gstary@cemm.oeaw.ac.at.ORCID https://orcid.org/0000-0002-2525-9399
Konstantin GüntherInstitute of Organic Chemistry, University of Vienna Währinger Straße 38 1090 Vienna Austria nuno.maulide@univie.ac.at.ORCID https://orcid.org/0000-0002-3874-1301
Martina DrescherInstitute of Organic Chemistry, University of Vienna Währinger Straße 38 1090 Vienna Austria nuno.maulide@univie.ac.at.
Florian DoubekInstitute of Organic Chemistry, University of Vienna Währinger Straße 38 1090 Vienna Austria nuno.maulide@univie.ac.at.
Daniel KaiserInstitute of Organic Chemistry, University of Vienna Währinger Straße 38 1090 Vienna Austria nuno.maulide@univie.ac.at.ORCID https://orcid.org/0000-0001-8895-9969
Georg StaryCeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences Lazarettgasse 14, AKH BT 25.3 1090 Vienna Austria gstary@cemm.oeaw.ac.at.ORCID https://orcid.org/0000-0003-1746-4250
Nuno MaulideInstitute of Organic Chemistry, University of Vienna Währinger Straße 38 1090 Vienna Austria nuno.maulide@univie.ac.at.ORCID https://orcid.org/0000-0003-3643-0718

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The macrocyclic immunosuppressive natural product (-)-FR252921 was isolated in 2003 from a liquid culture of

Identifiers

PMID42051982
PMCPMC13120711

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.