Evidence map›Paper›PMID 42051971›Full record

ArticleCase reports in anesthesiology2026

Double Trouble: Combined Prekallikrein and IgA Deficiencies in a Patient Undergoing Orthotopic Heart Transplantation-A Case Report.

Brittany McLay, Jocelyn E Coholich, Katelyn Glines, Jonathan A Bond, Mir Ali Abbas Khan, Brian P Peppers, Sonikpreet Aulakh

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Case reports in anesthesiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Brittany McLayDepartment of Anesthesiology, West Virginia University, Morgantown, West Virginia, USA, wvu.edu.ORCID https://orcid.org/0009-0009-0306-8821
Jocelyn E CoholichWest Virginia University School of Medicine, Charleston, West Virginia, USA, wvu.edu.
Katelyn GlinesDepartment of Anesthesiology, Southern Oregon Anesthesia, Medford, Oregon, USA, oregon.gov.ORCID https://orcid.org/0009-0000-7606-5095
Jonathan A BondDivision of Cardiac and Thoracic Anesthesiology, Department of Anesthesiology, West Virginia University, Morgantown, West Virginia, USA, wvu.edu.
Mir Ali Abbas KhanDivision of Cardiac and Thoracic Anesthesiology, Department of Anesthesiology, West Virginia University, Morgantown, West Virginia, USA, wvu.edu.
Brian P PeppersDepartment of Adult and Pediatric Allergy/Immunology, West Virginia University, Morgantown, West Virginia, USA, wvu.edu.
Sonikpreet AulakhDepartment of Medical Oncology, West Virginia University, Morgantown, West Virginia, USA, wvu.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Prekallikrein (PK) and selective IgA deficiencies are rare, and their coexistence in a cardiac transplant patient presents unique challenges. These disorders affect anticoagulation monitoring and transfusion safety, necessitating tailored perioperative strategies. We present the case of a 58-year-old female with both PK and IgA deficiency who underwent orthotopic heart transplantation (OHT), complicated by significant postoperative bleeding requiring re-exploration. A multidisciplinary plan included FFP-based IgA desensitization and correction of elevated ACT from PK deficiency. Anti-Xa levels were used to confirm anticoagulation. The patient tolerated unwashed blood products without anaphylaxis and recovered uneventfully. This is the first known report of combined PK and IgA deficiencies in cardiac surgery. It highlights a successful strategy involving perioperative FFP administration for both desensitization and ACT normalization. These measures ensured safe anticoagulation and transfusion in a high-risk setting.

Indexed as

cardiac transplantationcase reportIgA deficiencyprekallikrein deficiencytransfusion

Identifiers

PMID42051971
PMCPMC13112076

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.