The relationship between sonographically assessed volumetric brain development in VLBW preterm infants and neurodevelopmental outcome at 2 years of age-data from the NeoNEVS project.

C Brickmann, R Lampe, I Sidorenko, N Gauger, J Hauer, M Krüger, S Loth

Abstract read

In one paragraph

Article in Frontiers in pediatrics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

Neurodevelopmental Outcome in Very Low Birth Weight Preterm Infants: An Exploratory Multivariable Analysis Including Sonographic Brain Volume Trajectories-Data from the NeoNEVS Project.Children (Basel, Switzerland) · 2026
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

C BrickmannDepartment of Neonatology, TUM University Hospital, Technical University of Munich, TUM School of Medicine and Health, Munich, Germany.

R LampeDepartment of Clinical Medicine, Center for Digital Health and Technology, Orthopedic Department, Research Unit for Paediatric Neuroorthopedics and Cerebral Palsy of the Buhl-Strohmaier Foundation, Klinikum Rechts der Isar, School of Medicine and Health, Technical University of Munich, Munich, Germany.

I SidorenkoDepartment of Clinical Medicine, Center for Digital Health and Technology, Orthopedic Department, Research Unit for Paediatric Neuroorthopedics and Cerebral Palsy of the Buhl-Strohmaier Foundation, Klinikum Rechts der Isar, School of Medicine and Health, Technical University of Munich, Munich, Germany.

N GaugerClinic for Neonatology, Muenchen Klinik GGmbH, Munich, Germany.

J HauerTUM School of Medicine and Health, Department of Pediatrics, Kinderklinik Muenchen Schwabing, TUM University Hospital, Technical University of Munich, Munich, Germany.

M KrügerClinic for Neonatology, Muenchen Klinik GGmbH, Munich, Germany.

S LothTUM School of Medicine and Health, Department of Pediatrics, Kinderklinik Muenchen Schwabing, TUM University Hospital, Technical University of Munich, Munich, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Very low birth weight (VLBW) preterm infants are at increased risk for long-term neurodevelopmental impairment. Early identification of infants at risk remains challenging, particularly with regard to dynamic brain development during neonatal intensive care. Cranial ultrasound (CUS) allows safe and repeated bedside assessment of cerebral growth over time. Methods: In this retrospective cohort study, 79 VLBW infants (<1,500 g, <32 weeks gestation) treated at two tertiary neonatal intensive care units between 2019 and 2021 were included. Serial cranial ultrasound examinations were performed from birth to discharge. Total brain volume was estimated using a validated ellipsoid model, and individual cerebral growth rates were derived from longitudinal measurements. Neurodevelopmental outcome at 24 months corrected age was assessed using the Bayley Scales of Infant and Toddler Development, Third Edition (Bayley-III), reporting percentile ranks for cognitive, language, motor, and a combined developmental score. Associations were evaluated using Spearman correlation and multivariable linear regression. Results: The median cerebral brain growth rate was 2.4 cm

Indexed as

Bayley III = bayley scale of infant developmentbrain growthcerebral ultrasoundneurodevelopmentVLBW (very low birth weight)

Identifiers

PMID42051944

DOI10.3389/fped.2026.1769403

PMCPMC13111570

What OpenQuestion holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.