Effects of Intravenous Bolus Injection of Fentanyl on Phrenic Nerve Activity and Its Response to Hypoxia and Hypercapnia.

Jianguo Zhuang, Xiuping Gao, Shan Shi, Fadi Xu

Abstract read

In one paragraph

Article in Journal of pharmacy and pharmacology research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

Carfentanil Depresses Inspiratory Motor Drive.Journal of substance abuse and alcoholism · 2026
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Jianguo ZhuangDepartment of Physiology, Lovelace Biomedical Research Institute, Albuquerque, NM 87108.

Xiuping GaoDepartment of Physiology, Lovelace Biomedical Research Institute, Albuquerque, NM 87108.

Shan ShiDepartment of Physiology, Lovelace Biomedical Research Institute, Albuquerque, NM 87108.

Fadi XuDepartment of Physiology, Lovelace Biomedical Research Institute, Albuquerque, NM 87108.

Funding

Mechanism and Countermeasure of Fentanyl-Induced Sudden DeathR01HL163512 · NHLBI · LOVELACE BIOMEDICAL RESEARCH INSTITUTE · PI Fadi Xu · 2023 to 2026

$3.7M

Mechanism and Countermeasure of Carfentanil-induced Respiratory Disorder and DeathR01DA059063 · NIDA · LOVELACE BIOMEDICAL RESEARCH INSTITUTE · PI XU, FADI · 2023 to 2025

$2.0M

NHLBI NIH HHS R01 HL163512NIDA NIH HHS R01 DA059063

6 · The paper itself

Abstract

Intravenous bolus (IVb) injection of overdose fentanyl triggers an immediate apnea followed by severely depressed ventilation with several associated effects, such as upper airway constriction, respiratory muscle rigidity, hypoxemia/hypercapnia (due to hypoventilation) and hypothermia. This study sought to determine the direct impact of IVb injection of fentanyl on phrenic nerve activity (PN) over time in anesthetized, vagotomized, paralyzed and ventilated rats to avoid the associated effects. The integrative PN (ʃPN), frequency of ʃPN (f

Indexed as

cardiovascular activityInspiratory motor drivevagotomy

Identifiers

PMID42051927

PMCPMC13120783

What OpenQuestion holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.