Evidence map›Paper›PMID 42051852›Full record

ArticleBrain communications2026

Connectome disruptions after hypoxic-ischaemic injury associate with consciousness disorder severity.

Sofia G Hilger, Eric S Rosenthal, Annelise M Kulpanowski, Jacob A Dodelson, Gaston Cudemus-Deseda, Marjorie Villien, Brian L Edlow, James L Januzzi, MingMing Ning, W Taylor Kimberly and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Sofia G HilgerAthinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA.
Eric S RosenthalDepartment of Neurology, Massachusetts General Hospital, Boston, MA 02114, USA.
Annelise M KulpanowskiAthinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA.
Jacob A DodelsonAthinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA.
Gaston Cudemus-DesedaDepartment of Cardiac Anesthesiology and Critical Care Medicine, Massachusetts General Hospital, Boston, MA 02114, USA.
Marjorie VillienAthinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA.
Brian L EdlowAthinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA.ORCID https://orcid.org/0000-0001-7235-8456
James L JanuzziDepartment of Medicine, Cardiology Division, Massachusetts General Hospital and Baim Institute for Clinical Research, Boston, MA 02114, USA.
MingMing NingDepartment of Neurology, Massachusetts General Hospital, Boston, MA 02114, USA.
W Taylor KimberlyDepartment of Neurology, Massachusetts General Hospital, Boston, MA 02114, USA.
Edilberto AmorimDepartment of Neurology, Massachusetts General Hospital, Boston, MA 02114, USA.
M Brandon WestoverBeth Israel Deaconess Medical Center, Boston, MA 02215, USA.
William A CopenDepartment of Radiology, Neuroradiology Division, Massachusetts General Hospital, Boston, MA 02114, USA.
Pamela W SchaeferDepartment of Radiology, Neuroradiology Division, Massachusetts General Hospital, Boston, MA 02114, USA.
Joseph T GiacinoDepartment of Physical Medicine and Rehabilitation, Spaulding Rehabilitation Hospital, Harvard Medical School, Charlestown, MA 02129, USA.
David M GreerDepartment of Neurology, Boston University School of Medicine, Boston Medical Center, Boston, MA 02118, USA.
Ona WuAthinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA.ORCID https://orcid.org/0000-0002-5509-9461

Funding

Training and Dissemination CoreP41EB030006 · NIBIB · MASSACHUSETTS GENERAL HOSPITAL · PI Susie Yi Huang · 2020 to 2026
$10.9M
Multimodal Network Connectivity Architecture (MOCA) of the Brain and its Role in the Recovery of Consciousness in Comatose Cardiac Arrest PatientsR01NS102574 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI GREER, DAVID MATTHEW, WU, ONA · 2018 to 2022
$3.4M
NIBIB NIH HHS P41 EB030006NINDS NIH HHS R01 NS102574
6 · The paper itself

Abstract

Accurate neuroprognostication of cardiac arrest survivors who are initially comatose after restoration of spontaneous circulation is crucial for guiding patient management. Because hypoxic-ischaemic injury is typically diffuse, damage to a network of brain regions is likely involved in the patient's disorder of consciousness. To quantify these complex brain network changes, graph theoretical methods were applied. We hypothesize that structural connectivity metrics may provide insights into which patients will likely recover consciousness. Eighteen comatose patients (50 ± 22 years, 44% male) and four healthy participants (40 ± 20 years, 50% male) underwent multi-shell high angular diffusion MRI as part of a prospective study. Structural connectivity matrices were constructed using probabilistic tractography to measure the likelihood of connections between anatomical regions. Network topology alterations were quantified using clustering coefficient, global efficiency and degree. Hub index analysis was performed to explore the impact of anoxic injury on high-degree hubs. Network parameters were compared between patients with arousal recovery (AR, eye-opening to auditory or noxious stimulation) and without arousal recovery (No AR). Analyses were repeated for AR patients who achieved emergence from the minimally conscious state (EMCS) within one-year post-cardiac arrest and AR patients who did not achieve EMCS (AR'). Significant differences were observed between the Controls, AR and No AR for all four metrics (Kruskal-Wallis Tests,

Indexed as

brain connectivitydiffusion MRIdisorders of consciousnesshypoxic ischaemic brain injurystructural connectome

Identifiers

PMID42051852
PMCPMC13111490

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.