ArticleFrontiers in medicine2026
Effects of catheter-based extradural collagenase chemonucleolysis on pain scores and lumbar function in patients with lumbar disc herniation.
Article in Frontiers in medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Aim: Lumbar disc herniation (LDH) is a leading cause of radicular pain and disability. While conventional intradiscal collagenase chemonucleolysis (ICCN) is a minimally invasive alternative to surgery, it is limited by suboptimal drug targeting and recurrence. Catheter-based extradural collagenase chemonucleolysis (CECCN) was developed to deliver the enzyme directly to the herniated fragment. This research aimed to compare the clinical efficacy and safety of CECCN versus ICCN. Methods: A total of 300 patients with single-level, symptomatic lumbar disc herniation refractory to conservative treatment were included. The CECCN group ( Results: Operation time was longer in the CECCN group ( Conclusion: CECCN is more effective than conventional ICCN for relieving pain, improving function and quality of life, and reducing complications in LDH patients. The superior outcomes support its role as an advanced percutaneous treatment option, despite a longer procedural time.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.