ArticleFrontiers in medicine2026
Hypoxemia burden and atherogenic indices in OSAS: changes after CPAP therapy.
Article in Frontiers in medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objective: To evaluate the association between nocturnal hypoxemia burden-expressed as the percentage of total sleep time spent below 90% oxygen saturation (%T90/TST)-and atherogenic indices, including the atherogenic index of plasma (AIP), Castelli risk index I (CRI-I), and Castelli risk index II (CRI-II), in obstructive sleep apnea syndrome (OSAS); and to assess pre-post changes after adherent continuous positive airway pressure (CPAP) therapy. Methods: Single-centre retrospective-prospective cohort of adults with moderate-severe OSAS. Hypoxemia burden was quantified as the percentage of total sleep time with peripheral oxygen saturation (SpO₂) < 90% (%T90/TST) and grouped as Low (≤5%), Mild (>5-≤10%), Moderate (>10-≤25%), and Severe (>25%). The lipid panel-total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), triglycerides (TG)-and atherogenic indices (AIP, CRI-I, CRI-II) were compared across %T90 groups and within patients before and after ≥3 months of adherent CPAP (device-verified ≥4 h/night on ≥70% of nights). Results: One hundred and four patients were included. Higher %T90 was associated with a progressively more atherogenic profile: LDL-C ( Conclusion: In OSAS, greater hypoxemia burden (%T90/TST) is linked to a more atherogenic lipid profile, and adherent CPAP is associated with a meaningful reduction in atherogenic load (AIP, CRI-I/II). These findings indicate that nocturnal hypoxaemia, captured using index-based measurements (AIP, Castelli I/II) as well as traditional lipids, is associated with a general reduction in atherogenic risk.
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