Evidence map›Paper›PMID 42051719›Full record

ArticleFrontiers in medicine2026

The ratio of LDL-C to HDL-C can effectively predict the prognosis of IgA nephropathy.

Ya Hu, Wanwan Zhao, Dongdong Mei, Ganxiu Li, Sishi Lin, Chaosheng Chen

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Article in Frontiers in medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

6 authors.

Ya HuDepartment of Nephrology, Fuyang People's Hospital Affiliated to Anhui Medical University, Fuyang, Anhui, China.
Wanwan ZhaoDepartment of Nephrology, Fuyang People's Hospital Affiliated to Anhui Medical University, Fuyang, Anhui, China.
Dongdong MeiDepartment of Nephrology, Fuyang People's Hospital Affiliated to Anhui Medical University, Fuyang, Anhui, China.
Ganxiu LiDepartment of Nephrology, Fuyang People's Hospital Affiliated to Anhui Medical University, Fuyang, Anhui, China.
Sishi LinDepartment of Nephrology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China.
Chaosheng ChenDepartment of Nephrology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Abnormal lipid metabolism affects IgA nephropathy (IgAN) prognosis, but the prognostic value of LDL-C/HDL-C ratio in IgAN remains unclear. Methods: A bicenter retrospective cohort study enrolled 1,405 IgAN patients with a median follow-up of 50.1 months. Patients were divided into four quartiles based on LDL-C/HDL-C ratio (Q1: lowest quartile, Q4: highest quartile). Kaplan-Meier, Cox regression, and restricted cubic spline (RCS) analyses were used to explore the association between LDL-C/HDL-C ratio and end-stage renal disease (ESRD) risk. Results: ESRD occurred in 110 patients (8.45%). The ESRD-free survival rate decreased significantly with increasing LDL-C/HDL-C quartiles (log-rank Conclusion: Elevated LDL-C/HDL-C ratio constitutes an independent risk factor for end-stage renal disease (ESRD) in patients with IgA nephropathy (IgAN), demonstrating a linear dose-response relationship and serving as a reliable prognostic biomarker independent of IgA deposition.

Indexed as

ESRDIgA nephropathyimmunoglobulinLDL-C/HDL-Clipid metabolismprognosis

Identifiers

PMID42051719
PMCPMC13111122

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