ReviewJournal of clinical and experimental dentistry2026
Evaluation of alveolar ridge preservation using collagen and platelet-rich fibrin: A systematic review.
Review in Journal of clinical and experimental dentistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Alveolar ridge resorption following tooth extraction may compromise future implant placement and aesthetic outcomes. Several biomaterials have been proposed to limit post-extraction dimensional changes, among which collagen-based materials and platelet-rich fibrin (PRF) are widely used. The aim of this systematic review was to evaluate the effectiveness of collagen and PRF in alveolar ridge preservation compared with spontaneous healing. Material and Methods: This systematic review was conducted according to PRISMA 2020 guidelines and registered in PROSPERO (CRD42024489237). An electronic search was performed in PubMed, Scopus to identify randomized controlled trials (RCTs) published from 2014 onwards. Studies conducted in adult humans that evaluated horizontal and/or vertical alveolar ridge changes after tooth extraction were included. Risk of bias was assessed using the Cochrane RoB 2 tool. Results: Sixteen RCTs were included. Collagen-based interventions, particularly when combined with bone grafts such as deproteinized bovine bone mineral (DBBM), demonstrated a significant reduction in vertical and horizontal bone loss compared with spontaneous healing in several studies. PRF-based protocols showed heterogeneous results regarding dimensional bone preservation, with limited benefit when PRF was used alone. However, PRF-especially advanced or recurrent applications-was consistently associated with improved soft tissue healing and reduced postoperative pain. Considerable heterogeneity was observed in biomaterial preparation, application protocols, follow-up duration, and outcome assessment. Conclusions: Both collagen and PRF can contribute to alveolar ridge preservation after tooth extraction, although their clinical benefits differ. Collagen, particularly when combined with bone grafts, appears more effective in preserving alveolar dimensions, while PRF provides greater advantages in soft tissue healing and postoperative pain control. The choice of biomaterial should be guided by the clinical objective and extraction site. Further well-designed, standardized long-term RCTs are needed to establish definitive clinical recommendations.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.