ArticleMaternal-fetal medicine (Wolters Kluwer Health, Inc.)2026
Correlations Between Pregnancy-Associated Plasma Protein A Levels and Pregnancy Characteristics, Placental Volume, Vascularization, and Histopathology.
Article in Maternal-fetal medicine (Wolters Kluwer Health, Inc.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objective: To evaluate the associations between pregnancy-associated plasma protein A (PAPP-A) levels and pregnancy-associated conditions, perinatal outcomes, and placental histopathology. Methods: This retrospective, single-center cohort analysis included cases of preterm and term deliveries from pregnancies complicated by preeclampsia and fetal growth restriction or gestational hypertension. A correlation analysis was performed to assess the relationship between PAPP-A levels and neonatal parameters, the prevalence of various pregnancy complications, and placental and birth weight percentiles and ratios. Associations between placental histopathological entities and PAPP-A were explored in different subgroups defined by PAPP-A multiple of the median (MoM) ranges. Potential associations between PAPP-A levels and placental capillarization were also investigated. Results: A total of 74 pregnancies were investigated. PAPP-A levels were significantly lower in cases involving cesarean section ( Conclusion: Lower PAPP-A levels may represent an early marker of pathological placentation in the background of preeclampsia and fetal growth restriction-especially in early-onset cases-which are characterized by villous underdevelopment and a non-branching villous tree pattern on placental histopathology. From a clinical translation perspective, PAPP-A levels may serve as a potential early indicator of pregnancies that warrant close monitoring during clinical management.
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