ArticlemedRxiv : the preprint server for health sciences2026
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Article in medRxiv : the preprint server for health sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Authors and funding
136 authors.
C A Robert WarmerdamDepartment of Genetics, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.ORCID 0000-0001-8691-0053
Harm-Jan WestraDepartment of Genetics, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.ORCID 0000-0001-7038-567X
Adriaan van der GraafDepartment of Computational Biology, University of Lausanne, Lausanne, Switzerland.ORCID 0000-0002-8898-8484
Marc Jan BonderDepartment of Genetics, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.ORCID 0000-0002-8431-3180
Patrick DeelenDepartment of Genetics, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.ORCID 0000-0002-5654-3966
Tijs van LieshoutDepartment of Genetics, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.ORCID 0000-0003-0441-0309
Anke Jannie LandmanDepartment of Genetics, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.
Mihkel JesseInstitute of Computer Science, University of Tartu, Tartu, Estonia.ORCID 0009-0008-6108-411X
Benjamin J StroberComputational Health Informatics Program, Boston Children's Hospital, Boston, MA, USA.
Toni BoltzDepartment of Human Genetics, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA.ORCID 0000-0003-0226-7924
Sandra LapinskaBioinformatics Interdepartmental Program, University of California Los Angeles, Los Angeles, CA, USA.
Sini NagpalCenter for Integrative Genomics, Georgia Institute of Technology, Atlanta, GA, USA.ORCID 0000-0002-6624-6228
Manke XieCenter for Integrative Genomics, Georgia Institute of Technology, Atlanta, GA, USA.
Darwin TayLee Kong Chian School of Medicine, Nanyang Technological University, Singapore.
Holger KirstenLIFE - Leipzig Research Center for Civilization Diseases, Leipzig University, Leipzig, Germany.ORCID 0000-0002-3126-7950
Haroon NaeemSidra Medicine, Doha, Qatar.ORCID 0000-0001-9019-8345
Venket RaghavanInstitute for Medical Informatics, Statistics and Epidemiology, Leipzig University, Leipzig, Germany.ORCID 0000-0003-1378-2657
Aiman FarzeenInstitute of Neurogenomics, Computational Health Center, Helmholtz Munich, Neuherberg, Germany.
Alexander TeumerDepartment of Psychiatry and Psychotherapy, University Medicine Greifswald, Greifswald, Germany.ORCID 0000-0002-8309-094X
Marie-Julie FavéConcordia University, Centre for Functional and Structural Genomics, Biology department, Montreal, Canada.ORCID 0000-0002-9121-7584
Elodie PersynBritish Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.ORCID 0000-0001-9104-1972
Alex TokolyiWellcome Sanger Institute, Wellcome Genome Campus, Hinxton, UK.ORCID 0000-0003-4222-7484
René PoolDepartment of Biological Psychology, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands.ORCID 0000-0001-5579-0933
Jouke Jan HottengaNeurological Disorder Research Center, Qatar Biomedical Research Institute (QBRI), Hamad Bin Khalifa University (HBKU), Qatar Foundation, Doha P.O. Box 5825, Qatar.ORCID 0000-0002-5668-2368
Ruth D RodríguezPfizer-University of Granada-Junta de Andalucía Centre for Genomics and Oncological Research, Granada, Spain.ORCID 0009-0001-0711-8373
María Rivas-TorrubiaPfizer-University of Granada-Junta de Andalucía Centre for Genomics and Oncological Research, Granada, Spain.ORCID 0009-0006-6515-2947
Binisha Hamal MishraDepartment of Clinical Chemistry, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.ORCID 0000-0002-5605-5196
Brandon PierceBiological Sciences Division, Public Health Sciences, University of Chicago, Chicago, IL, USA.
Lin TongBiological Sciences Division, Public Health Sciences, University of Chicago, Chicago, IL, USA.
Qingbo S WangDepartment of Genome Informatics, Graduate School of Medicine, the University of Tokyo, Tokyo, Japan.ORCID 0000-0002-9110-5830
Takanori HasegawaM&D Data Science Center, Tokyo Medical and Dental University, Tokyo, Japan.ORCID 0000-0001-7251-9950
Surya B ChhetriDepartment of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, USA.
Diptavo DuttaDivision of Cancer Epidemiology & Genetics, National Cancer Institute, Bethesda, MD, USA.ORCID 0000-0002-6634-9040
Stefan WeissInterfaculty Institute of Genetics and Functional Genomics, University Medicine Greifswald, Greifswald, 17475, Germany.ORCID 0000-0002-3553-4315
Théo DupuisPopulation Health and Genomics, University of Dundee, Dundee, Scotland, UK.ORCID 0000-0002-5057-6222
Leo-Pekka LyytikäinenDepartment of Clinical Chemistry, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.ORCID 0000-0002-7200-5455
Pashupati P MishraDepartment of Clinical Chemistry, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.ORCID 0000-0001-5177-3431
Andrew R WoodCollege of Medicine and Health, University of Exeter, Exeter, UK.
Katie L BurnhamWellcome Sanger Institute, Wellcome Genome Campus, Hinxton, UK.ORCID 0000-0001-8680-2933
Jia WenDepartment of Genetics, University of North Carolina, Chapel Hill, NC, USA.
Evans CheruiyotInstitute for Molecular Bioscience, The University of Queensland, Brisbane, Australia.
Collins K BoahenDepartment of Internal Medicine and Radboud Institute of Molecular Life Sciences (RIMLS), Radboud University Medical Center, Nijmegen, 6525 HP, the Netherlands.
Rick JansenDepartment of Psychiatry, Amsterdam Public Health (Mental Health program) and Amsterdam Neuroscience (Mood, Anxiety, Psychosis, Stress and Sleep Program) Research Institutes, Amsterdam UMC Location Vrije University Amsterdam, Amsterdam, Netherlands.
Knut KrohnMedical Faculty, University of Leipzig, Leipzig, Germany.ORCID 0000-0001-8110-1273
Joachim ThieryLIFE - Leipzig Research Center for Civilization Diseases, Leipzig University, Leipzig, Germany.ORCID 0000-0001-7606-1852
IMI DIRECT Consortium
Kensuke DaidaIntegrative Neurogenomics Unit, Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA.ORCID 0000-0002-9177-9587
J Raphael GibbsComputational Biology Group, Laboratory of Neurogenetics, National Institute on Aging, Bethesda, MD, USA.ORCID 0000-0002-6985-0658
Joost VerlouwDepartment of Internal Medicine, Erasmus MC University Medical Center, Rotterdam, the Netherlands.ORCID 0000-0003-2373-0981
Viktorija KukushkinaEstonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia.
Reedik MägiEstonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia.
John BuddeDepartment of Psychiatry, Washington University School of Medicine, St. Louis, MO, United States.
Matt JohnsonDepartment of Psychiatry, Washington University School of Medicine, St. Louis, MO, United States.
Jessie SanfordDepartment of Psychiatry, Washington University School of Medicine, St. Louis, MO, United States.
Eline SlagboomSection of Molecular Epidemiology, Department of Biomedical Data Sciences, Leiden University Medical Center, Leiden, the Netherlands.
Frank BeutnerDepartment of Internal Medicine/Cardiology, Heart Center Leipzig at Leipzig University, Leipzig, Germany.
Markus LoefflerInstitute for Medical Informatics, Statistics and Epidemiology, Leipzig University, Leipzig, Germany.
PRECISESADS Clinical Consortium
Javier MartinInstituto de Parasitología y Biomedicina López-Neyra, Consejo Superior de Investigaciones Científicas (IPBLN-CSIC), Granada, Spain.ORCID 0000-0002-2202-0622
Emma RaitoharjuMolecular Epidemiology, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.ORCID 0000-0002-7023-8706
Muhammad G KibriyaBiological Sciences Division, Public Health Sciences, University of Chicago, Chicago, IL, USA.ORCID 0000-0001-9784-6958
Farzana JasmineBiological Sciences Division, Public Health Sciences, University of Chicago, Chicago, IL, USA.ORCID 0000-0002-5980-1174
Matthias NauckInstitute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, Greifswald, Germany.
HELIOS Study Team
Juan Carlos SoutoUnit of Genomics of Complex Diseases, Institut de Recerca Sant Pau (IR Sant Pau), Sant Quintí 77-79, 08041 Barcelona, Spain.ORCID 0000-0003-2092-5142
Angel Martinez-PerezUnit of Genomics of Complex Diseases, Institut de Recerca Sant Pau (IR Sant Pau), Sant Quintí 77-79, 08041 Barcelona, Spain.ORCID 0000-0002-5934-1454
M Arfan IkramDepartment of Epidemiology, Erasmus MC University Medical Center, Rotterdam, the Netherlands.
Juha MykkänenCentre for Population Health Research, University of Turku and Turku University Hospital, Turku, Finland.ORCID 0000-0001-9898-2660
Katja PahkalaResearch Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland.ORCID 0000-0001-9338-4397
Suvi P RovioResearch Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland.ORCID 0000-0003-0911-7478
Laura M RaffieldDepartment of Genetics, University of North Carolina, Chapel Hill, NC, USA.ORCID 0000-0002-7892-193X
Marleen van GreevenbroekCardiovascular Research Institute Maastricht (CARIM), Maastricht University, Maastricht, the Netherlands.ORCID 0000-0002-2989-1631
Carla J H van der KallenCardiovascular Research Institute Maastricht (CARIM), Maastricht University, Maastricht, the Netherlands.ORCID 0000-0003-1468-8793
Casper G SchalkwijkCardiovascular Research Institute Maastricht (CARIM), Maastricht University, Maastricht, the Netherlands.
Jan VeldinkDepartment of Neurology, UMC Utrecht Brain Center Rudolf Magnus, Utrecht, the Netherlands.ORCID 0000-0001-5572-9657
Krista FreimannInstitute of Computer Science, University of Tartu, Tartu, Estonia.ORCID 0009-0005-0212-6891
Martijn VochtelooDepartment of Genetics, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.ORCID 0000-0002-6385-0550
Anoek KooijmansDepartment of Genetics, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.ORCID 0009-0005-4271-3353
Lilia OuadahDepartment of Genetics, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.ORCID 0009-0004-4845-6354
Annique ClaringbouldDepartment of Internal Medicine, Erasmus MC, Erasmus University Medical Center Rotterdam, Rotterdam, the Netherlands.ORCID 0000-0002-9201-6557
Yunfeng HuangBiomarkers and Systems Biology, Research, Biogen, Cambridge, MA, USA.ORCID 0000-0003-2120-3328
Julien BryoisComputational Sciences Center of Excellence, F. Hoffmann-La Roche Ltd., Basel, Switzerland.ORCID 0000-0002-4747-2166
Ellen A TsaiBiomarkers and Systems Biology, Research, Biogen, Cambridge, MA, USA.
Matthias HeinigInstitute of Computational Biology, German Research Center for Environmental Health, Helmholtz Zentrum München, Neuherberg, Germany.ORCID 0000-0002-5612-1720
Monique G P van der WijstDepartment of Genetics, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.
Estonian Biobank Research Team
sc-eQTLGen Consortium
Vinod KumarDepartment of Internal Medicine and Radboud Institute of Molecular Life Sciences (RIMLS), Radboud University Medical Center, Nijmegen, 6525 HP, the Netherlands.
Peter M VisscherInstitute for Molecular Bioscience, The University of Queensland, Brisbane, Australia.ORCID 0000-0002-2143-8760
Allan F McRaeInstitute for Molecular Bioscience, The University of Queensland, Brisbane, Australia.
Grant W MontgomeryInstitute for Molecular Bioscience, The University of Queensland, Brisbane, Australia.ORCID 0000-0002-4140-8139
Yun LiDepartment of Biostatistics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.ORCID 0000-0002-9275-4189
Julian C KnightCentre for Human Genetics, University of Oxford, Oxford, UK.ORCID 0000-0002-0377-5536
Andrew SingletonLaboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA.
Luigi FerrucciTranslational Gerontology Branch, National Institute on Aging, National Institutes of Health, Baltimore, MD, USA.ORCID 0000-0002-6273-1613
Timothy M FraylingDepartment of Genetic Medicine and Development, CMU, University of Geneva.
Andrew BrownPopulation Health and Genomics, University of Dundee, Dundee, Scotland, UK.ORCID 0000-0002-8087-3033
José Manuel SoriaUnit of Genomics of Complex Diseases, Institut de Recerca Sant Pau (IR Sant Pau), Sant Quintí 77-79, 08041 Barcelona, Spain.ORCID 0000-0002-6226-4293
Uwe VölkerInterfaculty Institute of Genetics and Functional Genomics, University Medicine Greifswald, Greifswald, 17475, Germany.ORCID 0000-0002-5689-3448
Alexis BattleDepartment of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, USA.ORCID 0000-0002-5287-627X
Yukinori OkadaDepartment of Genome Informatics, Graduate School of Medicine, the University of Tokyo, Tokyo, Japan.ORCID 0000-0002-0311-8472
Koichi FukunagaDivision of Pulmonary Medicine, Department of Medicine, Keio University School of Medicine, Tokyo, Japan.
Ho NamkoongDepartment of Infectious Diseases, Keio University School of Medicine, Tokyo, Japan.
Habibul AhsanBiological Sciences Division, Institute for Population and Precision Health (IPPH), University of Chicago, Chicago, IL, USA.ORCID 0000-0001-9808-377X
Terho LehtimäkiDepartment of Clinical Chemistry, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.ORCID 0000-0002-2555-4427
Mika KähönenFinnish Cardiovascular Research Center Tampere, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.ORCID 0000-0002-4510-7341
Olli T RaitakariResearch Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland.ORCID 0000-0001-9365-3702
Marta E Alarcón-RiquelmePfizer-University of Granada-Junta de Andalucía Centre for Genomics and Oncological Research, Granada, Spain.ORCID 0000-0002-7632-4154
Guillermo BarturenDepartment of Genetics, Faculty of Science, University of Granada, 18071 Granada, Spain.
Brenda W J H PenninxDepartment of Psychiatry, Amsterdam Public Health (Mental Health program) and Amsterdam Neuroscience (Mood, Anxiety, Psychosis, Stress and Sleep Program) Research Institutes, Amsterdam UMC Location Vrije University Amsterdam, Amsterdam, Netherlands.ORCID 0000-0001-7779-9672
Dirk S PaulBritish Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.ORCID 0000-0002-8230-0116
Michael InouyeBritish Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
Philip AwadallaOntario Institute for Cancer Research, Toronto, Ontario, Canada.
Yun Ju SungDepartment of Psychiatry, Washington University School of Medicine, St. Louis, MO, United States.
Carlos CruchagaDepartment of Psychiatry, Washington University School of Medicine, St. Louis, MO, United States.ORCID 0000-0002-0276-2899
Joyce van MeursDepartment of Internal Medicine, Erasmus MC University Medical Center, Rotterdam, the Netherlands.
Holger ProkischSchool of Medicine, Institute of Human Genetics, Technical University of Munich, Munich, Germany.
Annette PetersInstitute of Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany.ORCID 0000-0001-6645-0985
Christian GiegerResearch Unit of Molecular Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany.
Cornelis BlauwendraatIntegrative Neurogenomics Unit, Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA.
Younes MokrabSidra Medicine, Doha, Qatar.
Emma E DavenportWellcome Sanger Institute, Wellcome Genome Campus, Hinxton, UK.ORCID 0000-0002-8768-346X
Markus ScholzInstitute for Medical Informatics, Statistics and Epidemiology, Leipzig University, Leipzig, Germany.ORCID 0000-0002-4059-1779
Marie LohLee Kong Chian School of Medicine, Nanyang Technological University, Singapore.ORCID 0000-0003-3626-8466
John ChambersLee Kong Chian School of Medicine, Nanyang Technological University, Singapore.
Greg GibsonCenter for Integrative Genomics, Georgia Institute of Technology, Atlanta, GA, USA.ORCID 0000-0002-5352-5877
Dorret I BoomsmaDepartment of Complex Trait Genetics, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, the Netherlands.ORCID 0000-0002-7099-7972
Ana ViñuelaBiosciences Institute, Faculty of Medical Sciences, University of Newcastle, Newcastle upon Tyne, UK.ORCID 0000-0003-3771-8537
Bogdan PasaniucDepartment of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.ORCID 0000-0002-0227-2056
Roel OphoffBioinformatics Interdepartmental Program, University of California Los Angeles, Los Angeles, CA, USA.ORCID 0000-0002-8287-6457
Alkes L PriceDepartment of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA.ORCID 0000-0002-2971-7975
Kaur AlasooInstitute of Computer Science, University of Tartu, Tartu, Estonia.ORCID 0000-0002-1761-8881
Zoltan KutalikDepartment of Computational Biology, University of Lausanne, Lausanne, Switzerland.ORCID 0000-0001-8285-7523
Tõnu EskoEstonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia.
Lude H FrankeDepartment of Genetics, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.
Urmo VõsaEstonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia.ORCID 0000-0003-3476-1652
Funding
Joint genomic and statistical analyses of schizophrenia and bipolar to decipher genetic susceptibilityR01MH115676 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Roel A Ophoff, Bogdan Pasaniuc · 2018 to 2026
$5.9MPredicting the impact of genetic variants, genes and pathways on human DiseaseU01HG012009 · NHGRI · BRIGHAM AND WOMEN'S HOSPITAL · PI ALKES L PRICE, Soumya Raychaudhuri · 2021 to 2026
$4.2MImmune Cells in Alzheimer’s Disease and Related Dementias in the Jackson Heart StudyR01AG075884 · NIA · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Laura M Raffield · 2022 to 2026
$3.7MModeling the dynamicimpact of rare and common genetic variation on gene expression anddiseaseR35GM139580 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI BATTLE, ALEXIS · 2021 to 2025
$3.1MNHGRI NIH HHS U01 HG012009NIA NIH HHS R01 AG075884NIGMS NIH HHS R35 GM139580NIMH NIH HHS R01 MH115676Wellcome Trust
Abstract
Many non-coding variants influence complex traits and diseases through gene regulation, yet the mechanisms linking these variants to downstream biology remain poorly understood. Here, we present
Indexed as
cis-eQTLscolocalization analysiscomplex traitseQTL mappingfine-mappinggene regulatory networkspopulation geneticstrans-eQTLs
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