Evidence map›Paper›PMID 42051358›Full record

ReviewEuropean heart journal open2026

Beyond the conventional risk factors in the management of atherosclerosis in women: a call to action for careful consideration of obesity and inflammation.

Mirvat Alasnag, Antonia Sambola, Izabella Uchmanowicz, Marta Kaluzna, Pierre François Sabouret, Laura Serrano, Valeria Paradies, Biljana Parapid, Shrilla Banerjee, Anne Bachelot and 6 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in European heart journal open, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Mirvat AlasnagCardiac Center, King Fahd Armed Forces Hospital, PO Box 126418, Alcorniche Jeddah 21372, Saudi Arabia.ORCID https://orcid.org/0000-0002-8714-0334
Antonia Sambolad'Hebron Hospital Universitari Vall d'Hebron Paseo Vall d'Hebron, 119-129 08035 Barcelona, Spain.ORCID https://orcid.org/0000-0003-3939-5559
Izabella UchmanowiczDepartment of Laboratory Diagnostics, 4th Military Hospital of Wroclaw, Weigla 5, 50-981, Wroclaw, Poland.
Marta Kaluzna1st Department of Cardiology, Medical University in Poznan, 10 Fredry Street, Poznan, Poland.ORCID https://orcid.org/0000-0003-4048-6247
Pierre François SabouretInstitute of Cardiology Hôpital Pitié-Salpêtrière (AP-HP), ACTION Study Group, Sorbonne University, 47-83 Boulevard de l'Hôpital, 75013 Paris, France.
Laura SerranoCardiocean Clinic, Puilboreau, 13080 Aix-en-Provence, France.ORCID https://orcid.org/0009-0002-3110-0322
Valeria ParadiesCardiology Department, Maasstad Hospital, Maasstad Ziekenhuis Maasstadweg 21, 3079 DZ Rotterdam, KvK 24299846, Rotterdam, The Netherlands.ORCID https://orcid.org/0000-0003-3513-7819
Biljana ParapidDivision of Cardiology, University Clinical Center of Serbia, Faculty of Medicine, University of Belgrade, Studentski trg 1, 11102 Belgrade 3, Serbia.ORCID https://orcid.org/0000-0002-1071-2496
Shrilla BanerjeeDepartment of Cardiology, Surrey and Sussex Healthcare, East Surrey Hospital, Canada Avenue, Redhill, Surrey RH1 5RH, UK.ORCID https://orcid.org/0000-0002-3702-7616
Anne BachelotAP-HP, Hôpitaux Universitaires Pitié-Salpêtrière, Service d'Endocrinologie et Médecine de la Reproduction, Sorbonne Université, 47-83 boulevard de l'Hôpital, Paris 75013, France.
Martine GilardCardiology Department, CHU Brest, Boulevard Tanguy Prigent, Brest 29209, France.ORCID https://orcid.org/0000-0002-2794-7953
Michał Hawranek3rd Department of Cardiology, Faculty of Medical Sciences in Zabrze, Medical University of Silesia, 5 Poniatowskiego Street, 40-055 Katowice, Poland.
Vijay KunadianTranslational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University and Cardiothoracic Centre, Freeman Hospital, Newcastle upon Tyne Hospitals, NHS Foundation Trust, Royal Victoria Infirmary, Queen Victoria Road, Newcastle upon Tyne NE1 4LP, UK.ORCID https://orcid.org/0000-0003-2975-6971
Alaide ChieffoOspedale San Raffaele, Università Vita-Salute San Raffaele Facoltà di Medicina e Chirurgia, Università degli Studi di Napoli Federico II Dipartimento di Medicina Clinica e Chirurgia, Via Olgettina, 60, 20132 Milano MI, Italy.ORCID https://orcid.org/0000-0002-3505-9112
Roxana MehranMount Sinai Fuster Heart Hospital, Icahn School of Medicine at Mount Sinai, 190 Fifth Avenue and 1468 Madison Avenue, New York, USA.ORCID https://orcid.org/0000-0002-5546-262X
Stephane Manzo SilbermanInstitute of Cardiology Hôpital Pitié-Salpêtrière (AP-HP), ACTION Study Group, Sorbonne University, 47-83 Boulevard de l'Hôpital, 75013 Paris, France.ORCID https://orcid.org/0000-0002-0703-1331

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Conventional risk factors do not completely explain the burden of atherosclerotic cardiovascular disease (ASCVD) in women. Obesity and chronic low-grade inflammation are recognized as important contributors to atherosclerotic risk. This viewpoint explains the role of obesity-driven inflammation in the development and management of atherosclerosis in women. Abdominal obesity promotes a proinflammatory and prothrombotic environment that accelerates atherogenesis. Women with higher inflammatory biomarker levels and experience sex-specific risk-modifying stages, such as polycystic ovary syndrome, pregnancy-related conditions, and menopause, have higher risk for cardiovascular events, including atherosclerosis. We review evidence for antiobesity and anti-inflammatory therapies. Integrating obesity and inflammation into ASCVD care in women requires targeted screening, risk assessment, and sex-stratified research approaches. This viewpoint highlights the relation between obesity and atherosclerosis.

Indexed as

AtherosclerosisInflammationObesityRisk factorsWomen

Identifiers

PMID42051358
PMCPMC13111925

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.