ArticleFrontiers in nutrition2026
Icariin improves metabolic response to exercise by promoting TFEB-dependent mitochondrial clearance and metabolic reprogramming in C57BL/6 mice and C2C12 myotubes.
Article in Frontiers in nutrition, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Fatigue during intensive exercise is closely associated with metabolic inefficiency and lactate accumulation. While Icariin, a natural flavonoid, has demonstrated potential in enhancing exercise performance, the precise cellular mechanisms governing its anti-fatigue effects remain incompletely elucidated. Methods: We employed an integrated approach combining Results: Icariin supplementation dose-dependently enhanced exercise performance, evidenced by increased maximal oxygen consumption (VO Conclusion: Our findings establish a comprehensive mechanistic pathway wherein Icariin activates TFEB to drive mitophagic clearance of dysfunctional mitochondria, thereby optimizing mitochondrial function and shifting energy metabolism toward oxidative phosphorylation. This TFEB-mitophagy axis represents the core mechanism through which Icariin enhances exercise performance and metabolic efficiency, providing novel insights into its anti-fatigue properties and potential therapeutic applications.
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