Evidence map›Paper›PMID 42051317›Full record

ArticlebioRxiv : the preprint server for biology2026

SATB1 is a targetable modulator of JAK-STAT signaling and cytokines in human Treg and Tconv cells.

Saskia Kolb, Leonie Diekmann, Elizabeth D Lochert, Linda Warmuth, Julia Ritter, Michael Weber, Markus Hoffmann, Markus List, Daniel Kotlarz, Isabelle Serr and 4 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors.

Saskia KolbTechnical University of Munich (TUM), School of Medicine and Health, Department of Preclinical Medicine, Institute for Medical Microbiology, Immunology and Hygiene, Munich 81675, Germany.
Leonie DiekmannTechnical University of Munich (TUM), School of Medicine and Health, Department of Preclinical Medicine, Institute for Medical Microbiology, Immunology and Hygiene, Munich 81675, Germany.
Elizabeth D LochertTechnical University of Munich (TUM), School of Medicine and Health, Department of Preclinical Medicine, Institute for Medical Microbiology, Immunology and Hygiene, Munich 81675, Germany.
Linda WarmuthTechnical University of Munich (TUM), School of Medicine and Health, Department of Preclinical Medicine, Institute for Medical Microbiology, Immunology and Hygiene, Munich 81675, Germany.
Julia RitterTechnical University of Munich (TUM), School of Medicine and Health, Department of Preclinical Medicine, Institute for Medical Microbiology, Immunology and Hygiene, Munich 81675, Germany.
Michael WeberTUM, German Heart Center. Department of Anaesthiology, Munich 80636, Germany.
Markus HoffmannTechnical University of Munich (TUM), School of Life Sciences, Department of Data Science of Systems Biology, Freising 85354, Germany.
Markus ListTechnical University of Munich (TUM), School of Life Sciences, Department of Data Science of Systems Biology, Freising 85354, Germany.ORCID 0000-0002-0941-4168
Daniel KotlarzLudwig Maximilians University (LMU), Department of Pediatrics, Dr von Hauner Children's Hospital, University Hospital, Munich 80337, Germany.
Isabelle SerrResearch Unit Type 1 Diabetes Immunology, Helmholtz Diabetes Center at Helmholtz Zentrum München, 80939 Munich, Germany.
Carolin DanielResearch Unit Type 1 Diabetes Immunology, Helmholtz Diabetes Center at Helmholtz Zentrum München, 80939 Munich, Germany.
Dirk H BuschTechnical University of Munich (TUM), School of Medicine and Health, Department of Preclinical Medicine, Institute for Medical Microbiology, Immunology and Hygiene, Munich 81675, Germany.
Christian SchmidlLeibniz Institute for Immunotherapy, Regensburg 93053, Germany.
Kathrin SchumannTechnical University of Munich (TUM), School of Medicine and Health, Department of Preclinical Medicine, Institute for Medical Microbiology, Immunology and Hygiene, Munich 81675, Germany.ORCID 0000-0002-0993-3910

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The chromatin organizer SATB1 is indispensable for thymic regulatory T cell (Treg cell) development and T helper cell induction. Several gene loci have been described to be SATB1-controlled, including the transcription factor GATA3 and the cytokine loci IL-4 and IL-17. However, the global effects of SATB1 on fully differentiated human CD4 conventional T cells (Tconv cells) and Treg cells, and thus SATB1`s potential as a target for T cell engineering, are poorly understood. We describe SATB1-regulated gene signatures as largely subset-specific, with broader effects on Treg cells. Despite of the distinct gene-regulatory patterns, we observe overarching dysregulated cytokine and JAK-STAT signaling after

Indexed as

cytokineJAK-STATSATB1TconvTreg

Identifiers

PMID42051317
PMCPMC13119340

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.