Evidence map›Paper›PMID 42051290›Full record

ArticlebioRxiv : the preprint server for biology2026

The human DEAD-box protein DDX3X regulates host and viral mRNA translation during Sendai Virus infection.

Cathal S Ryan, Dimitrios G Anastasakis, Ahsan H Polash, Elizabeth Sitko, Markus Hafner, Martina Schröder

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Cathal S RyanBiology Department, Maynooth University Ireland, Maynooth, Co. Kildare, Ireland.ORCID 0000-0002-2925-2952
Dimitrios G AnastasakisRNA Molecular Biology Laboratory, National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), National Institutes of Health (NIH), Bethesda, Maryland, USA.ORCID 0000-0003-2306-275X
Ahsan H PolashRNA Molecular Biology Laboratory, National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), National Institutes of Health (NIH), Bethesda, Maryland, USA.ORCID 0000-0002-6591-3164
Elizabeth SitkoBiology Department, Maynooth University Ireland, Maynooth, Co. Kildare, Ireland.ORCID 0009-0004-9781-8382
Markus HafnerRNA Molecular Biology Laboratory, National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), National Institutes of Health (NIH), Bethesda, Maryland, USA.ORCID 0000-0002-4336-6518
Martina SchröderBiology Department, Maynooth University Ireland, Maynooth, Co. Kildare, Ireland.ORCID 0000-0003-1899-6048

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

DDX3X is a multifunctional DEAD-box RNA helicase with important roles in translation initiation and antiviral innate immune signaling, yet it is currently unknown whether viral infection affects its interactions with host RNAs. Here, we define the transcriptome-wide binding landscape of endogenous DDX3X in Sendai virus-infected human cells using PAR-CLIP. We show that DDX3X maintains its preference for GC-rich, highly structured 5'UTR regions during infection, but acquires a distinct set of infection-induced targets, including

Identifiers

PMID42051290
PMCPMC13119317

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.